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Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to their unique chemical, physical, and biological properties and functions. In this comprehensive review, we present recent advance in the material design, functional regulation, and SCI repair applications of...

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Detalles Bibliográficos
Autores principales: Sun, Zhengang, Zhu, Danzhu, Zhao, Hong, Liu, Jia, He, Peng, Luan, Xin, Hu, Huiqiang, Zhang, Xuanfen, Wei, Gang, Xi, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364437/
https://www.ncbi.nlm.nih.gov/pubmed/37488557
http://dx.doi.org/10.1186/s12951-023-01996-y
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author Sun, Zhengang
Zhu, Danzhu
Zhao, Hong
Liu, Jia
He, Peng
Luan, Xin
Hu, Huiqiang
Zhang, Xuanfen
Wei, Gang
Xi, Yongming
author_facet Sun, Zhengang
Zhu, Danzhu
Zhao, Hong
Liu, Jia
He, Peng
Luan, Xin
Hu, Huiqiang
Zhang, Xuanfen
Wei, Gang
Xi, Yongming
author_sort Sun, Zhengang
collection PubMed
description Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to their unique chemical, physical, and biological properties and functions. In this comprehensive review, we present recent advance in the material design, functional regulation, and SCI repair applications of bioactive hydrogels. Different from previously released reviews on hydrogels and three-dimensional scaffolds for the SCI repair, this work focuses on the strategies for material design and biologically functional regulation of hydrogels, specifically aiming to show how these significant efforts can promoting the repairing performance of SCI. We demonstrate various methods and techniques for the fabrication of bioactive hydrogels with the biological components such as DNA, proteins, peptides, biomass polysaccharides, and biopolymers to obtain unique biological properties of hydrogels, including the cell biocompatibility, self-healing, anti-bacterial activity, injectability, bio-adhesion, bio-degradation, and other multi-functions for repairing SCI. The functional regulation of bioactive hydrogels with drugs/growth factors, polymers, nanoparticles, one-dimensional materials, and two-dimensional materials for highly effective treating SCI are introduced and discussed in detail. This work shows new viewpoints and ideas on the design and synthesis of bioactive hydrogels with the state-of-the-art knowledges of materials science and nanotechnology, and will bridge the connection of materials science and biomedicine, and further inspire clinical potential of bioactive hydrogels in biomedical fields.
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spelling pubmed-103644372023-07-25 Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications Sun, Zhengang Zhu, Danzhu Zhao, Hong Liu, Jia He, Peng Luan, Xin Hu, Huiqiang Zhang, Xuanfen Wei, Gang Xi, Yongming J Nanobiotechnology Review Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to their unique chemical, physical, and biological properties and functions. In this comprehensive review, we present recent advance in the material design, functional regulation, and SCI repair applications of bioactive hydrogels. Different from previously released reviews on hydrogels and three-dimensional scaffolds for the SCI repair, this work focuses on the strategies for material design and biologically functional regulation of hydrogels, specifically aiming to show how these significant efforts can promoting the repairing performance of SCI. We demonstrate various methods and techniques for the fabrication of bioactive hydrogels with the biological components such as DNA, proteins, peptides, biomass polysaccharides, and biopolymers to obtain unique biological properties of hydrogels, including the cell biocompatibility, self-healing, anti-bacterial activity, injectability, bio-adhesion, bio-degradation, and other multi-functions for repairing SCI. The functional regulation of bioactive hydrogels with drugs/growth factors, polymers, nanoparticles, one-dimensional materials, and two-dimensional materials for highly effective treating SCI are introduced and discussed in detail. This work shows new viewpoints and ideas on the design and synthesis of bioactive hydrogels with the state-of-the-art knowledges of materials science and nanotechnology, and will bridge the connection of materials science and biomedicine, and further inspire clinical potential of bioactive hydrogels in biomedical fields. BioMed Central 2023-07-24 /pmc/articles/PMC10364437/ /pubmed/37488557 http://dx.doi.org/10.1186/s12951-023-01996-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Zhengang
Zhu, Danzhu
Zhao, Hong
Liu, Jia
He, Peng
Luan, Xin
Hu, Huiqiang
Zhang, Xuanfen
Wei, Gang
Xi, Yongming
Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title_full Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title_fullStr Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title_full_unstemmed Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title_short Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
title_sort recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364437/
https://www.ncbi.nlm.nih.gov/pubmed/37488557
http://dx.doi.org/10.1186/s12951-023-01996-y
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