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Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus

INTRODUCTION: Change in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM). METHODS: To understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnan...

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Autores principales: Lyu, Xuejing, Wang, Shaona, Zhong, Jiaxin, Cai, Lingzhu, Zheng, Yanhui, Zhou, Ying, Chen, Qionghua, Li, Qiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364628/
https://www.ncbi.nlm.nih.gov/pubmed/37492251
http://dx.doi.org/10.3389/fmicb.2023.1175065
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author Lyu, Xuejing
Wang, Shaona
Zhong, Jiaxin
Cai, Lingzhu
Zheng, Yanhui
Zhou, Ying
Zhou, Ying
Chen, Qionghua
Li, Qiyuan
author_facet Lyu, Xuejing
Wang, Shaona
Zhong, Jiaxin
Cai, Lingzhu
Zheng, Yanhui
Zhou, Ying
Zhou, Ying
Chen, Qionghua
Li, Qiyuan
author_sort Lyu, Xuejing
collection PubMed
description INTRODUCTION: Change in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM). METHODS: To understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites. RESULTS: We evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overrepresented metabolites of pregnancy hormone, butyrate and mevalonate, as potential intermediary metabolites of intestinal microbiota in GDM. Finally, we validated the impacts of the intestinal microbiota on GDM by demonstrating consistent changes of the serum levels of progesterone, estradiol, butyrate, and mevalonate in an independent cohort. DISCUSSION: Our findings confirm that alterations in the microbiota play a role in the development of GDM by impacting the metabolism of pregnancy hormones. This provides a novel perspective on the pathogenesis of GDM and introduces potential biomarkers that can be used for early diagnosis and prevention of the disease.
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spelling pubmed-103646282023-07-25 Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus Lyu, Xuejing Wang, Shaona Zhong, Jiaxin Cai, Lingzhu Zheng, Yanhui Zhou, Ying Zhou, Ying Chen, Qionghua Li, Qiyuan Front Microbiol Microbiology INTRODUCTION: Change in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM). METHODS: To understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites. RESULTS: We evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overrepresented metabolites of pregnancy hormone, butyrate and mevalonate, as potential intermediary metabolites of intestinal microbiota in GDM. Finally, we validated the impacts of the intestinal microbiota on GDM by demonstrating consistent changes of the serum levels of progesterone, estradiol, butyrate, and mevalonate in an independent cohort. DISCUSSION: Our findings confirm that alterations in the microbiota play a role in the development of GDM by impacting the metabolism of pregnancy hormones. This provides a novel perspective on the pathogenesis of GDM and introduces potential biomarkers that can be used for early diagnosis and prevention of the disease. Frontiers Media S.A. 2023-07-10 /pmc/articles/PMC10364628/ /pubmed/37492251 http://dx.doi.org/10.3389/fmicb.2023.1175065 Text en Copyright © 2023 Lyu, Wang, Zhong, Cai, Zheng, Zhou, Zhou, Chen and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lyu, Xuejing
Wang, Shaona
Zhong, Jiaxin
Cai, Lingzhu
Zheng, Yanhui
Zhou, Ying
Zhou, Ying
Chen, Qionghua
Li, Qiyuan
Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title_full Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title_fullStr Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title_full_unstemmed Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title_short Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
title_sort gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364628/
https://www.ncbi.nlm.nih.gov/pubmed/37492251
http://dx.doi.org/10.3389/fmicb.2023.1175065
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