Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover

Loss of the tumor suppressor protein menin is a critical event underlying the formation of neuroendocrine tumors (NET) in hormone-expressing tissues including gastrinomas. While aberrant expression of menin impairs its tumor suppression, few studies explore the structure–function relationship of cli...

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Detalles Bibliográficos
Autores principales: Duan, Suzann, Sheriff, Sulaiman, Elvis-Offiah, Uloma B., Witten, Brandon L., Sawyer, Travis W., Sundaresan, Sinju, Cierpicki, Tomasz, Grembecka, Jolanta, Merchant, Juanita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364643/
https://www.ncbi.nlm.nih.gov/pubmed/37492626
http://dx.doi.org/10.1158/2767-9764.CRC-22-0522

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