Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases

This study estimated the cost-effectiveness of liver transplantation in patients with colorectal liver metastases confined to the liver with progressive disease, compared with alternative treatment options: TAS-102, regorafenib, or best supportive care. Using a mathematical simulation model, people’...

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Autores principales: Bjørnelv, Gudrun M W, Zolic-Karlsson, Zinajda, Dueland, Svein, Line, Pål-Dag, Aas, Eline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364692/
https://www.ncbi.nlm.nih.gov/pubmed/35576387
http://dx.doi.org/10.1093/bjs/znac022
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author Bjørnelv, Gudrun M W
Zolic-Karlsson, Zinajda
Dueland, Svein
Line, Pål-Dag
Aas, Eline
author_facet Bjørnelv, Gudrun M W
Zolic-Karlsson, Zinajda
Dueland, Svein
Line, Pål-Dag
Aas, Eline
author_sort Bjørnelv, Gudrun M W
collection PubMed
description This study estimated the cost-effectiveness of liver transplantation in patients with colorectal liver metastases confined to the liver with progressive disease, compared with alternative treatment options: TAS-102, regorafenib, or best supportive care. Using a mathematical simulation model, people’s life expectancy and healthcare costs over 25 years were estimated. Transplanted patients lived for 4.28 years, more than 3 years longer than those who received alternative treatment options. Despite this, the high cost of liver transplantation meant that this treatment was cost-effective only at high willingness-to-pay thresholds.
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spelling pubmed-103646922023-07-31 Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases Bjørnelv, Gudrun M W Zolic-Karlsson, Zinajda Dueland, Svein Line, Pål-Dag Aas, Eline Br J Surg Short Report This study estimated the cost-effectiveness of liver transplantation in patients with colorectal liver metastases confined to the liver with progressive disease, compared with alternative treatment options: TAS-102, regorafenib, or best supportive care. Using a mathematical simulation model, people’s life expectancy and healthcare costs over 25 years were estimated. Transplanted patients lived for 4.28 years, more than 3 years longer than those who received alternative treatment options. Despite this, the high cost of liver transplantation meant that this treatment was cost-effective only at high willingness-to-pay thresholds. Oxford University Press 2022-03-12 /pmc/articles/PMC10364692/ /pubmed/35576387 http://dx.doi.org/10.1093/bjs/znac022 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Short Report
Bjørnelv, Gudrun M W
Zolic-Karlsson, Zinajda
Dueland, Svein
Line, Pål-Dag
Aas, Eline
Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title_full Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title_fullStr Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title_full_unstemmed Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title_short Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
title_sort cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364692/
https://www.ncbi.nlm.nih.gov/pubmed/35576387
http://dx.doi.org/10.1093/bjs/znac022
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