Ex situ machine preservation of donor livers for transplantation: HOPE for all?

Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have...

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Autores principales: van Leeuwen, O B, Porte, R J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Leading Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364854/
https://www.ncbi.nlm.nih.gov/pubmed/34476463
http://dx.doi.org/10.1093/bjs/znab293
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author van Leeuwen, O B
Porte, R J
author_facet van Leeuwen, O B
Porte, R J
author_sort van Leeuwen, O B
collection PubMed
description Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have been declined for transplantation. We advocate the combined use of (dual) HOPE and NMP for livers that are considered high risk, but may still be transplanted safely after ex situ resuscitation and assessment of hepatobiliary viability. Combined dual HOPE–NMP has the potential to substantially decrease the high rates of deceased donor liver discard.
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spelling pubmed-103648542023-07-31 Ex situ machine preservation of donor livers for transplantation: HOPE for all? van Leeuwen, O B Porte, R J Br J Surg Leading Article Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have been declined for transplantation. We advocate the combined use of (dual) HOPE and NMP for livers that are considered high risk, but may still be transplanted safely after ex situ resuscitation and assessment of hepatobiliary viability. Combined dual HOPE–NMP has the potential to substantially decrease the high rates of deceased donor liver discard. Oxford University Press 2021-09-03 /pmc/articles/PMC10364854/ /pubmed/34476463 http://dx.doi.org/10.1093/bjs/znab293 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Leading Article
van Leeuwen, O B
Porte, R J
Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title_full Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title_fullStr Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title_full_unstemmed Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title_short Ex situ machine preservation of donor livers for transplantation: HOPE for all?
title_sort ex situ machine preservation of donor livers for transplantation: hope for all?
topic Leading Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364854/
https://www.ncbi.nlm.nih.gov/pubmed/34476463
http://dx.doi.org/10.1093/bjs/znab293
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AT porterj exsitumachinepreservationofdonorliversfortransplantationhopeforall

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