Watchful waiting for small non-functional pancreatic neuroendocrine tumours: nationwide prospective cohort study (PANDORA)

This prospective nationwide cohort study examined the feasibility of a watchful-waiting protocol for non-functional pancreatic neuroendocrine tumours (NF-pNET) of 2 cm or smaller. In total, 8 of 76 patients (11 per cent) with a NF-pNET no larger than 2 cm showed significant tumour progression (more...

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Detalles Bibliográficos
Autores principales: Heidsma, C M, Engelsman, A F, van Dieren, S, Stommel, M W J, de Hingh, I, Vriens, M, Hol, L, Festen, S, Mekenkamp, L, Hoogwater, F J H, Daams, F, Klümpen, H -J, Besselink, M G, van Eijck, C H, Nieveen van Dijkum, E J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Rapid Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364894/
https://www.ncbi.nlm.nih.gov/pubmed/33783475
http://dx.doi.org/10.1093/bjs/znab088
Descripción
Sumario:This prospective nationwide cohort study examined the feasibility of a watchful-waiting protocol for non-functional pancreatic neuroendocrine tumours (NF-pNET) of 2 cm or smaller. In total, 8 of 76 patients (11 per cent) with a NF-pNET no larger than 2 cm showed significant tumour progression (more than 0.5 cm/year) during 17 months of follow-up, of whom two opted for resection. No patient developed metastases. Quality of life was poorer than in the reference population. Watchful waiting seems a safe alternative to upfront surgery in patients with a NF-pNET no larger than 2 cm, although longer follow-up is necessary.

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