The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

Fungal infections are responsible for significant morbidity and mortality. Resistance to the limited number of agents in the antifungal armamentarium among pathogenic fungi represents a growing public health threat. Particularly concerning is the emerging fungal pathogen Candida auris that frequentl...

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Autores principales: Rybak, Jeffrey M, Cuomo, Christina A, Rogers, P David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364995/
https://www.ncbi.nlm.nih.gov/pubmed/36242897
http://dx.doi.org/10.1016/j.mib.2022.102208
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author Rybak, Jeffrey M
Cuomo, Christina A
Rogers, P David
author_facet Rybak, Jeffrey M
Cuomo, Christina A
Rogers, P David
author_sort Rybak, Jeffrey M
collection PubMed
description Fungal infections are responsible for significant morbidity and mortality. Resistance to the limited number of agents in the antifungal armamentarium among pathogenic fungi represents a growing public health threat. Particularly concerning is the emerging fungal pathogen Candida auris that frequently exhibits resistance to the triazole class of antifungals and amphotericin B, and for which isolates resistant to all of the major antifungal classes have been reported. In this brief review, we provide an overview of what is currently known about the molecular and genetic basis for antifungal resistance in this fungal pathogen.
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spelling pubmed-103649952023-07-24 The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris Rybak, Jeffrey M Cuomo, Christina A Rogers, P David Curr Opin Microbiol Article Fungal infections are responsible for significant morbidity and mortality. Resistance to the limited number of agents in the antifungal armamentarium among pathogenic fungi represents a growing public health threat. Particularly concerning is the emerging fungal pathogen Candida auris that frequently exhibits resistance to the triazole class of antifungals and amphotericin B, and for which isolates resistant to all of the major antifungal classes have been reported. In this brief review, we provide an overview of what is currently known about the molecular and genetic basis for antifungal resistance in this fungal pathogen. 2022-12 2022-10-12 /pmc/articles/PMC10364995/ /pubmed/36242897 http://dx.doi.org/10.1016/j.mib.2022.102208 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This isan open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Rybak, Jeffrey M
Cuomo, Christina A
Rogers, P David
The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title_full The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title_fullStr The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title_full_unstemmed The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title_short The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
title_sort molecular and genetic basis of antifungal resistance in the emerging fungal pathogen candida auris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364995/
https://www.ncbi.nlm.nih.gov/pubmed/36242897
http://dx.doi.org/10.1016/j.mib.2022.102208
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