Cargando…

Heterogeneity in the gene regulatory landscape of leiomyosarcoma

Characterizing inter-tumor heterogeneity is crucial for selecting suitable cancer therapy, as the presence of diverse molecular subgroups of patients can be associated with disease outcome or response to treatment. While cancer subtypes are often characterized by differences in gene expression, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Belova, Tatiana, Biondi, Nicola, Hsieh, Ping-Han, Lutsik, Pavlo, Chudasama, Priya, Kuijjer, Marieke L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Cancer Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365024/ https://www.ncbi.nlm.nih.gov/pubmed/37492373 http://dx.doi.org/10.1093/narcan/zcad037

Ejemplares similares

The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
por: Kazachenka, Anastasiya, et al.
Publicado: (2023)

Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
por: He, Zan, et al.
Publicado: (2022)

Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme
por: Lopes-Ramos, Camila M., et al.
Publicado: (2021)

Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity
por: Tudose, Cosmin, et al.
Publicado: (2023)

Mechanistic models of signaling pathways deconvolute the glioblastoma single-cell functional landscape
por: Falco, Matías M, et al.
Publicado: (2020)

Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data
por: Spisak, Natanael, et al.
Publicado: (2020)

Heterogeneity of d-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer
por: Prudnikova, Tatiana Y, et al.
Publicado: (2013)

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells
por: Sahoo, Sarthak, et al.
Publicado: (2021)

Heterogeneity of the GFP fitness landscape and data-driven protein design
por: Gonzalez Somermeyer, Louisa, et al.
Publicado: (2022)

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape
por: Boot, James, et al.
Publicado: (2022)

The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia
por: Mansur, Marcela B., et al.
Publicado: (2021)

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
por: Trigos, Anna S, et al.
Publicado: (2019)

Mutational signatures and the genomic landscape of betel quid chewing‐associated tongue carcinoma
por: Zhang, Weilong, et al.
Publicado: (2019)

Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
por: Anantha, Rachel W, et al.
Publicado: (2017)

Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape
por: Farhy, Chen, et al.
Publicado: (2019)

Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis
por: Swarts, Dorian R. A., et al.
Publicado: (2018)

Intratumor heterogeneity: A new perspective on colorectal cancer research
por: Zheng, Zicheng, et al.
Publicado: (2020)

Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics
por: Gallaher, Jill, et al.
Publicado: (2023)

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
por: Tenente, Inês M, et al.
Publicado: (2017)

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways
por: Ahmed, Ibrahim, et al.
Publicado: (2023)

Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks
por: Hari, Kishore, et al.
Publicado: (2022)

Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations
por: Wong, Nelson K Y, et al.
Publicado: (2012)

Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors
por: Genovese, Sara, et al.
Publicado: (2019)

Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing
por: Bosisio, Francesca Maria, et al.
Publicado: (2020)

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants
por: Blanden, Adam R, et al.
Publicado: (2020)

Multimodality Cardiac Imaging Assessment of a Large Metastatic Pericardial Leiomyosarcoma
por: Sripariwuth, Apichaya, et al.
Publicado: (2018)

A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors
por: Crowley, Laura, et al.
Publicado: (2020)

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
por: Camolotto, Soledad A, et al.
Publicado: (2018)

MeDeCom: discovery and quantification of latent components of heterogeneous methylomes
por: Lutsik, Pavlo, et al.
Publicado: (2017)

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response
por: Lyu, Xiao‐Ming, et al.
Publicado: (2018)

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing
por: Baslan, Timour, et al.
Publicado: (2020)

Develop a circular RNA–related regulatory network associated with prognosis of gastric cancer
por: Wei, Shuxun, et al.
Publicado: (2020)

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones
por: Sarthy, Jay F, et al.
Publicado: (2020)

Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer
por: Yeo, Syn Kok, et al.
Publicado: (2020)

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
por: Chauhan, Lakshya, et al.
Publicado: (2021)

Gene-regulatory interactions in embryonic stem cells represent cell-type specific gene regulatory programs
por: Ha, Misook, et al.
Publicado: (2017)

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression
por: Nguyen, Kim Bich, et al.
Publicado: (2023)

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis
por: Dai, Xiangpeng, et al.
Publicado: (2014)

Spatiotemporal heterogeneity of tumor vasculature during tumor growth and antiangiogenic treatment: MRI assessment using permeability and blood volume parameters
por: Kim, Cherry, et al.
Publicado: (2018)

The landscape of human SVA retrotransposons
por: Chu, Chong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kftcfto2t7lcbmvfa30p6d9pt9