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Expression of CRY2 Gene in the Brain Is Related to Human Navigation

Navigation is a complex cognitive process. CRY2 gene has been proposed to play an important role in navigation behaviors in various non-human animal species. Utilizing a recently developed neuroimaging-transcriptomics approach, the present study reported a tentative link between the CRY2 gene and hu...

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Autores principales: Xu, Shan, Kong, Xiangzhen, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365100/
https://www.ncbi.nlm.nih.gov/pubmed/37492180
http://dx.doi.org/10.3389/fradi.2021.731070
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author Xu, Shan
Kong, Xiangzhen
Liu, Jia
author_facet Xu, Shan
Kong, Xiangzhen
Liu, Jia
author_sort Xu, Shan
collection PubMed
description Navigation is a complex cognitive process. CRY2 gene has been proposed to play an important role in navigation behaviors in various non-human animal species. Utilizing a recently developed neuroimaging-transcriptomics approach, the present study reported a tentative link between the CRY2 gene and human navigation. Specifically, we showed a significant pattern similarity between CRY2 gene expression in the human brain and navigation-related neural activation in functional magnetic resonance imaging. To further illuminate the functionality of CRY2 in human navigation, we examined the correlation between CRY2 expression and various cognitive processes underlying navigation, and found high correlation of CRY2 expression with neural activity of multiple cognitive domains, particularly object and shape perception and spatial memory. Further analyses on the relation between the neural activity of human navigation and the expression maps of genes of two CRY2-related pathways, i.e., the magnetoreceptive and circadian-related functions, found a trend of correlation for the CLOCK gene, a core circadian regulator gene, suggesting that CRY2 may modulate human navigation through its role in circadian rhythm. This observation was further confirmed by a behavioral study where individuals with better circadian regularity in daily life showed better sense of direction. Taken together, our study presents the first neural evidence that links CRY2 with human navigation, possibly through the modulation of circadian rhythm.
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spelling pubmed-103651002023-07-25 Expression of CRY2 Gene in the Brain Is Related to Human Navigation Xu, Shan Kong, Xiangzhen Liu, Jia Front Radiol Radiology Navigation is a complex cognitive process. CRY2 gene has been proposed to play an important role in navigation behaviors in various non-human animal species. Utilizing a recently developed neuroimaging-transcriptomics approach, the present study reported a tentative link between the CRY2 gene and human navigation. Specifically, we showed a significant pattern similarity between CRY2 gene expression in the human brain and navigation-related neural activation in functional magnetic resonance imaging. To further illuminate the functionality of CRY2 in human navigation, we examined the correlation between CRY2 expression and various cognitive processes underlying navigation, and found high correlation of CRY2 expression with neural activity of multiple cognitive domains, particularly object and shape perception and spatial memory. Further analyses on the relation between the neural activity of human navigation and the expression maps of genes of two CRY2-related pathways, i.e., the magnetoreceptive and circadian-related functions, found a trend of correlation for the CLOCK gene, a core circadian regulator gene, suggesting that CRY2 may modulate human navigation through its role in circadian rhythm. This observation was further confirmed by a behavioral study where individuals with better circadian regularity in daily life showed better sense of direction. Taken together, our study presents the first neural evidence that links CRY2 with human navigation, possibly through the modulation of circadian rhythm. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC10365100/ /pubmed/37492180 http://dx.doi.org/10.3389/fradi.2021.731070 Text en Copyright © 2021 Xu, Kong and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Radiology
Xu, Shan
Kong, Xiangzhen
Liu, Jia
Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title_full Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title_fullStr Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title_full_unstemmed Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title_short Expression of CRY2 Gene in the Brain Is Related to Human Navigation
title_sort expression of cry2 gene in the brain is related to human navigation
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365100/
https://www.ncbi.nlm.nih.gov/pubmed/37492180
http://dx.doi.org/10.3389/fradi.2021.731070
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