Cargando…
Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment
Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy (FA) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalities as opposed to other diffusion metrics in the disorder. We c...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365239/ https://www.ncbi.nlm.nih.gov/pubmed/37357976 http://dx.doi.org/10.1002/hbm.26405 |
_version_ | 1785076998740115456 |
---|---|
author | Canales‐Rodríguez, Erick Jorge Verdolini, Norma Alonso‐Lana, Silvia Torres, María Llanos Panicalli, Francesco Argila‐Plaza, Isabel Rodriguez‐Cano, Elena Montoro, Irene Garcia‐Ruiz, Beatriz Jimenez, Esther Varo, Cristina Lluch, Anna del Mar Bonnin, Caterina Maluf, Silvana Pujol, Marc Guarner, Núria Jaurrieta Sarró, Salvador Vieta, Eduard Vilella, Elisabet Salvador, Raymond Pomarol‐Clotet, Edith |
author_facet | Canales‐Rodríguez, Erick Jorge Verdolini, Norma Alonso‐Lana, Silvia Torres, María Llanos Panicalli, Francesco Argila‐Plaza, Isabel Rodriguez‐Cano, Elena Montoro, Irene Garcia‐Ruiz, Beatriz Jimenez, Esther Varo, Cristina Lluch, Anna del Mar Bonnin, Caterina Maluf, Silvana Pujol, Marc Guarner, Núria Jaurrieta Sarró, Salvador Vieta, Eduard Vilella, Elisabet Salvador, Raymond Pomarol‐Clotet, Edith |
author_sort | Canales‐Rodríguez, Erick Jorge |
collection | PubMed |
description | Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy (FA) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalities as opposed to other diffusion metrics in the disorder. We conducted a whole‐brain voxel‐based multicompartment diffusion MRI study on 316 participants (i.e., 158 patients and 158 matched healthy controls) employing four diffusion metrics: the mean diffusivity (MD) and FA estimated from DTI, and the intra‐axonal signal fraction (IASF) and microscopic axonal parallel diffusivity (Dpar) derived from the spherical mean technique. Our findings provide novel evidence about widespread abnormalities in other diffusion metrics in BD. An extensive overlap between the FA and IASF results suggests that the lower FA in patients may be caused by a reduced intra‐axonal volume fraction or a higher macromolecular content in the intra‐axonal water. We also found a diffuse alteration in MD involving white and grey matter tissue and more localised changes in Dpar. A Machine Learning analysis revealed that FA, followed by IASF, were the most helpful metric for the automatic diagnosis of BD patients, reaching an accuracy of 72%. Number of mood episodes, age of onset/duration of illness, psychotic symptoms, and current treatment with lithium, antipsychotics, antidepressants, and antiepileptics were all significantly associated with microstructure abnormalities. Lithium treatment was associated with less microstructure abnormality. |
format | Online Article Text |
id | pubmed-10365239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103652392023-07-25 Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment Canales‐Rodríguez, Erick Jorge Verdolini, Norma Alonso‐Lana, Silvia Torres, María Llanos Panicalli, Francesco Argila‐Plaza, Isabel Rodriguez‐Cano, Elena Montoro, Irene Garcia‐Ruiz, Beatriz Jimenez, Esther Varo, Cristina Lluch, Anna del Mar Bonnin, Caterina Maluf, Silvana Pujol, Marc Guarner, Núria Jaurrieta Sarró, Salvador Vieta, Eduard Vilella, Elisabet Salvador, Raymond Pomarol‐Clotet, Edith Hum Brain Mapp Research Articles Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy (FA) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalities as opposed to other diffusion metrics in the disorder. We conducted a whole‐brain voxel‐based multicompartment diffusion MRI study on 316 participants (i.e., 158 patients and 158 matched healthy controls) employing four diffusion metrics: the mean diffusivity (MD) and FA estimated from DTI, and the intra‐axonal signal fraction (IASF) and microscopic axonal parallel diffusivity (Dpar) derived from the spherical mean technique. Our findings provide novel evidence about widespread abnormalities in other diffusion metrics in BD. An extensive overlap between the FA and IASF results suggests that the lower FA in patients may be caused by a reduced intra‐axonal volume fraction or a higher macromolecular content in the intra‐axonal water. We also found a diffuse alteration in MD involving white and grey matter tissue and more localised changes in Dpar. A Machine Learning analysis revealed that FA, followed by IASF, were the most helpful metric for the automatic diagnosis of BD patients, reaching an accuracy of 72%. Number of mood episodes, age of onset/duration of illness, psychotic symptoms, and current treatment with lithium, antipsychotics, antidepressants, and antiepileptics were all significantly associated with microstructure abnormalities. Lithium treatment was associated with less microstructure abnormality. John Wiley & Sons, Inc. 2023-06-26 /pmc/articles/PMC10365239/ /pubmed/37357976 http://dx.doi.org/10.1002/hbm.26405 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Canales‐Rodríguez, Erick Jorge Verdolini, Norma Alonso‐Lana, Silvia Torres, María Llanos Panicalli, Francesco Argila‐Plaza, Isabel Rodriguez‐Cano, Elena Montoro, Irene Garcia‐Ruiz, Beatriz Jimenez, Esther Varo, Cristina Lluch, Anna del Mar Bonnin, Caterina Maluf, Silvana Pujol, Marc Guarner, Núria Jaurrieta Sarró, Salvador Vieta, Eduard Vilella, Elisabet Salvador, Raymond Pomarol‐Clotet, Edith Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title | Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title_full | Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title_fullStr | Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title_full_unstemmed | Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title_short | Widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
title_sort | widespread intra‐axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion mri: sensitivity to diagnosis, association with clinical features and pharmacologic treatment |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365239/ https://www.ncbi.nlm.nih.gov/pubmed/37357976 http://dx.doi.org/10.1002/hbm.26405 |
work_keys_str_mv | AT canalesrodriguezerickjorge widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT verdolininorma widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT alonsolanasilvia widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT torresmariallanos widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT panicallifrancesco widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT argilaplazaisabel widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT rodriguezcanoelena widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT montoroirene widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT garciaruizbeatriz widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT jimenezesther widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT varocristina widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT lluchanna widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT delmarbonnincaterina widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT malufsilvana widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT pujolmarc widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT guarnernuriajaurrieta widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT sarrosalvador widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT vietaeduard widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT vilellaelisabet widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT salvadorraymond widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment AT pomarolclotetedith widespreadintraaxonalsignalfractionabnormalitiesinbipolardisorderfrommulticompartmentdiffusionmrisensitivitytodiagnosisassociationwithclinicalfeaturesandpharmacologictreatment |