Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

A synergistic combination of in vitro electrophysiology and multicompartmental modeling of rat CA1 pyramidal neurons identified TRPM4 channels as major drivers of cholinergic modulation of the firing rate during a triangular current ramp, which emulates the bump in synaptic input received while trav...

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Detalles Bibliográficos
Autores principales: Combe, Crescent L, Upchurch, Carol M, Canavier, Carmen C, Gasparini, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365838/
https://www.ncbi.nlm.nih.gov/pubmed/37404129
http://dx.doi.org/10.7554/eLife.84387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365838/
https://www.ncbi.nlm.nih.gov/pubmed/37404129
http://dx.doi.org/10.7554/eLife.84387

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