Detection of mpox virus in ambient air in a sexual health clinic

Although transmitted mainly through direct (sexual) contact, mpox virus (MPXV) can be detected in ambient air. We explored the use of air sampling for diagnosis or (genomic) surveillance of mpox in a sexual health clinic. For six out of six patients who were infected with MPXV, all four of our ambie...

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Autores principales: Raymenants, Joren, Van Gestel, Liesbeth, Coppens, Jasmine, De Block, Tessa, Bangwen, Eugene, Rutgers, Jojanneke, Hens, Matilde, De Vos, Elise, Coppens, Sandra, Keyaerts, Els, André, Emmanuel, Rezende, Antonio Mauro, Van Esbroeck, Marjan, Vercauteren, Koen, Liesenborghs, Laurens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366007/
https://www.ncbi.nlm.nih.gov/pubmed/37486383
http://dx.doi.org/10.1007/s00705-023-05837-z
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author Raymenants, Joren
Van Gestel, Liesbeth
Coppens, Jasmine
De Block, Tessa
Bangwen, Eugene
Rutgers, Jojanneke
Hens, Matilde
De Vos, Elise
Coppens, Sandra
Keyaerts, Els
André, Emmanuel
Rezende, Antonio Mauro
Van Esbroeck, Marjan
Vercauteren, Koen
Liesenborghs, Laurens
author_facet Raymenants, Joren
Van Gestel, Liesbeth
Coppens, Jasmine
De Block, Tessa
Bangwen, Eugene
Rutgers, Jojanneke
Hens, Matilde
De Vos, Elise
Coppens, Sandra
Keyaerts, Els
André, Emmanuel
Rezende, Antonio Mauro
Van Esbroeck, Marjan
Vercauteren, Koen
Liesenborghs, Laurens
author_sort Raymenants, Joren
collection PubMed
description Although transmitted mainly through direct (sexual) contact, mpox virus (MPXV) can be detected in ambient air. We explored the use of air sampling for diagnosis or (genomic) surveillance of mpox in a sexual health clinic. For six out of six patients who were infected with MPXV, all four of our ambient air PCR tests were positive. For 14 uninfected patients, PCR was positive in three ambient air samples, albeit with higher cycle threshold (C(t)) values. Genomic sequencing of samples from two positive patients showed matching sequences between air and clinical samples. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-023-05837-z.
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spelling pubmed-103660072023-07-26 Detection of mpox virus in ambient air in a sexual health clinic Raymenants, Joren Van Gestel, Liesbeth Coppens, Jasmine De Block, Tessa Bangwen, Eugene Rutgers, Jojanneke Hens, Matilde De Vos, Elise Coppens, Sandra Keyaerts, Els André, Emmanuel Rezende, Antonio Mauro Van Esbroeck, Marjan Vercauteren, Koen Liesenborghs, Laurens Arch Virol Brief Report Although transmitted mainly through direct (sexual) contact, mpox virus (MPXV) can be detected in ambient air. We explored the use of air sampling for diagnosis or (genomic) surveillance of mpox in a sexual health clinic. For six out of six patients who were infected with MPXV, all four of our ambient air PCR tests were positive. For 14 uninfected patients, PCR was positive in three ambient air samples, albeit with higher cycle threshold (C(t)) values. Genomic sequencing of samples from two positive patients showed matching sequences between air and clinical samples. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-023-05837-z. Springer Vienna 2023-07-24 2023 /pmc/articles/PMC10366007/ /pubmed/37486383 http://dx.doi.org/10.1007/s00705-023-05837-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Raymenants, Joren
Van Gestel, Liesbeth
Coppens, Jasmine
De Block, Tessa
Bangwen, Eugene
Rutgers, Jojanneke
Hens, Matilde
De Vos, Elise
Coppens, Sandra
Keyaerts, Els
André, Emmanuel
Rezende, Antonio Mauro
Van Esbroeck, Marjan
Vercauteren, Koen
Liesenborghs, Laurens
Detection of mpox virus in ambient air in a sexual health clinic
title Detection of mpox virus in ambient air in a sexual health clinic
title_full Detection of mpox virus in ambient air in a sexual health clinic
title_fullStr Detection of mpox virus in ambient air in a sexual health clinic
title_full_unstemmed Detection of mpox virus in ambient air in a sexual health clinic
title_short Detection of mpox virus in ambient air in a sexual health clinic
title_sort detection of mpox virus in ambient air in a sexual health clinic
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366007/
https://www.ncbi.nlm.nih.gov/pubmed/37486383
http://dx.doi.org/10.1007/s00705-023-05837-z
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