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Kynurenine Pathway in Psoriasis—a Promising Link?
Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome. Pathogenesis remains unknown; however, genetic, environmental and immunological factors seem to play a role in the devel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366053/ https://www.ncbi.nlm.nih.gov/pubmed/37326759 http://dx.doi.org/10.1007/s13555-023-00958-4 |
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author | Stepaniuk, A. Baran, A. Flisiak, I. |
author_facet | Stepaniuk, A. Baran, A. Flisiak, I. |
author_sort | Stepaniuk, A. |
collection | PubMed |
description | Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome. Pathogenesis remains unknown; however, genetic, environmental and immunological factors seem to play a role in the development of the disease. Due to a lack of complete understanding of the psoriasis pathology, effective treatment is yet to be developed. The kynurenine pathway is one of the ways amino acid tryptophan is metabolised. In comorbidities typical for psoriasis such as chronic kidney disease, depression and atherosclerotic alterations in the activation of the kynurenine pathway were observed, which were mainly characterised by higher activity compared to that in healthy individuals. However, the kynurenine pathway has not been thoroughly studied among patients with psoriasis even though increased levels of l-kynurenine, one of the enzymes in the kynurenine pathway, were found in psoriatic skin lesions. Given the unknown pathogenesis of the disease, this finding seems to be a potential new field of study and shows a possible link between psoriasis and its comorbidities that could also lead to novel effective treatment for this chronic condition. |
format | Online Article Text |
id | pubmed-10366053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-103660532023-07-26 Kynurenine Pathway in Psoriasis—a Promising Link? Stepaniuk, A. Baran, A. Flisiak, I. Dermatol Ther (Heidelb) Review Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome. Pathogenesis remains unknown; however, genetic, environmental and immunological factors seem to play a role in the development of the disease. Due to a lack of complete understanding of the psoriasis pathology, effective treatment is yet to be developed. The kynurenine pathway is one of the ways amino acid tryptophan is metabolised. In comorbidities typical for psoriasis such as chronic kidney disease, depression and atherosclerotic alterations in the activation of the kynurenine pathway were observed, which were mainly characterised by higher activity compared to that in healthy individuals. However, the kynurenine pathway has not been thoroughly studied among patients with psoriasis even though increased levels of l-kynurenine, one of the enzymes in the kynurenine pathway, were found in psoriatic skin lesions. Given the unknown pathogenesis of the disease, this finding seems to be a potential new field of study and shows a possible link between psoriasis and its comorbidities that could also lead to novel effective treatment for this chronic condition. Springer Healthcare 2023-06-16 /pmc/articles/PMC10366053/ /pubmed/37326759 http://dx.doi.org/10.1007/s13555-023-00958-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Stepaniuk, A. Baran, A. Flisiak, I. Kynurenine Pathway in Psoriasis—a Promising Link? |
title | Kynurenine Pathway in Psoriasis—a Promising Link? |
title_full | Kynurenine Pathway in Psoriasis—a Promising Link? |
title_fullStr | Kynurenine Pathway in Psoriasis—a Promising Link? |
title_full_unstemmed | Kynurenine Pathway in Psoriasis—a Promising Link? |
title_short | Kynurenine Pathway in Psoriasis—a Promising Link? |
title_sort | kynurenine pathway in psoriasis—a promising link? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366053/ https://www.ncbi.nlm.nih.gov/pubmed/37326759 http://dx.doi.org/10.1007/s13555-023-00958-4 |
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