Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers

Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are required cell-autonomously for efficient production of neu...

Descripción completa

Detalles Bibliográficos
Autores principales: Arnold, Meghan Lee, Cooper, Jason, Androwski, Rebecca, Ardeshna, Sohil, Melentijevic, Ilija, Smart, Joelle, Guasp, Ryan J., Nguyen, Ken C. Q., Bai, Ge, Hall, David H., Grant, Barth D., Driscoll, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366101/
https://www.ncbi.nlm.nih.gov/pubmed/37488107
http://dx.doi.org/10.1038/s41467-023-39700-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366101/
https://www.ncbi.nlm.nih.gov/pubmed/37488107
http://dx.doi.org/10.1038/s41467-023-39700-1

Ejemplares similares