ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins

Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains unclear. We show that the ORC1 subunit of the human Origin R...

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Detalles Bibliográficos
Autores principales: Mas, Aina Maria, Goñi, Enrique, Ruiz de los Mozos, Igor, Arcas, Aida, Statello, Luisa, González, Jovanna, Blázquez, Lorea, Lee, Wei Ting Chelsea, Gupta, Dipika, Sejas, Álvaro, Hoshina, Shoko, Armaos, Alexandros, Tartaglia, Gian Gaetano, Waga, Shou, Ule, Jernej, Rothenberg, Eli, Gómez, María, Huarte, Maite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366126/
https://www.ncbi.nlm.nih.gov/pubmed/37488096
http://dx.doi.org/10.1038/s41467-023-40105-3

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