RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles

RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysis. Here we report the RAD51C-XRCC3 (CX3) X-ray co-crystal s...

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Detalles Bibliográficos
Autores principales: Longo, Michael A., Roy, Sunetra, Chen, Yue, Tomaszowski, Karl-Heinz, Arvai, Andrew S., Pepper, Jordan T., Boisvert, Rebecca A., Kunnimalaiyaan, Selvi, Keshvani, Caezanne, Schild, David, Bacolla, Albino, Williams, Gareth J., Tainer, John A., Schlacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366140/
https://www.ncbi.nlm.nih.gov/pubmed/37488098
http://dx.doi.org/10.1038/s41467-023-40096-1

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