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PHB2 ameliorates Doxorubicin-induced cardiomyopathy through interaction with NDUFV2 and restoration of mitochondrial complex I function

BACKGROUND: Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity. Earlier studies described an essential role of mitochondrial injury in the pathogenesis of DOX cardiomyopathy. PHB2 (Prohibitin 2)...

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Detalles Bibliográficos
Autores principales:	Yang, Mingjie, Abudureyimu, Miyesaier, Wang, Xiang, Zhou, Yuan, Zhang, Yingmei, Ren, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366351/ https://www.ncbi.nlm.nih.gov/pubmed/37451140 http://dx.doi.org/10.1016/j.redox.2023.102812

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