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Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies

Osteosarcoma is a highly aggressive and metastatic malignant tumor. It has the highest incidence of all malignant bone tumors and is one of the most common solid tumors in children and adolescents. Osteosarcoma tissues are often richly infiltrated with inflammatory cells, including tumor-associated...

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Autores principales: Ying, Hui, Li, Zhi-Qiang, Li, Meng-Pan, Liu, Wen-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366376/
https://www.ncbi.nlm.nih.gov/pubmed/37497349
http://dx.doi.org/10.3389/fendo.2023.1217669
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author Ying, Hui
Li, Zhi-Qiang
Li, Meng-Pan
Liu, Wen-Cai
author_facet Ying, Hui
Li, Zhi-Qiang
Li, Meng-Pan
Liu, Wen-Cai
author_sort Ying, Hui
collection PubMed
description Osteosarcoma is a highly aggressive and metastatic malignant tumor. It has the highest incidence of all malignant bone tumors and is one of the most common solid tumors in children and adolescents. Osteosarcoma tissues are often richly infiltrated with inflammatory cells, including tumor-associated macrophages, lymphocytes, and dendritic cells, forming a complex immune microenvironment. The expression of immune checkpoint molecules is also high in osteosarcoma tissues, which may be involved in the mechanism of anti-tumor immune escape. Metabolism and senescence are closely related to the immune microenvironment, and disturbances in metabolism and senescence may have important effects on the immune microenvironment, thereby affecting immune cell function and immune responses. Metabolic modulation and anti-senescence therapy are gaining the attention of researchers as emerging immunotherapeutic strategies for tumors. Through an in-depth study of the interconnection of metabolism and anti- senescence in the tumor immune microenvironment and its regulatory mechanism on immune cell function and immune response, more precise therapeutic strategies can be developed. Combined with the screening and application of biomarkers, personalized treatment can be achieved to improve therapeutic efficacy and provide a scientific basis for clinical decision-making. Metabolic modulation and anti- senescence therapy can also be combined with other immunotherapy approaches, such as immune checkpoint inhibitors and tumor vaccines, to form a multi-level and multi-dimensional immunotherapy strategy, thus further enhancing the effect of immunotherapy. Multidisciplinary cooperation and integrated treatment can optimize the treatment plan and maximize the survival rate and quality of life of patients. Future research and clinical practice will further advance this field, promising more effective treatment options for patients with osteosarcoma. In this review, we reviewed metabolic and senescence characteristics in the immune microenvironment of osteosarcoma and related immunotherapies, and provide a reference for development of more personalized and effective therapeutic strategies.
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spelling pubmed-103663762023-07-26 Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies Ying, Hui Li, Zhi-Qiang Li, Meng-Pan Liu, Wen-Cai Front Endocrinol (Lausanne) Endocrinology Osteosarcoma is a highly aggressive and metastatic malignant tumor. It has the highest incidence of all malignant bone tumors and is one of the most common solid tumors in children and adolescents. Osteosarcoma tissues are often richly infiltrated with inflammatory cells, including tumor-associated macrophages, lymphocytes, and dendritic cells, forming a complex immune microenvironment. The expression of immune checkpoint molecules is also high in osteosarcoma tissues, which may be involved in the mechanism of anti-tumor immune escape. Metabolism and senescence are closely related to the immune microenvironment, and disturbances in metabolism and senescence may have important effects on the immune microenvironment, thereby affecting immune cell function and immune responses. Metabolic modulation and anti-senescence therapy are gaining the attention of researchers as emerging immunotherapeutic strategies for tumors. Through an in-depth study of the interconnection of metabolism and anti- senescence in the tumor immune microenvironment and its regulatory mechanism on immune cell function and immune response, more precise therapeutic strategies can be developed. Combined with the screening and application of biomarkers, personalized treatment can be achieved to improve therapeutic efficacy and provide a scientific basis for clinical decision-making. Metabolic modulation and anti- senescence therapy can also be combined with other immunotherapy approaches, such as immune checkpoint inhibitors and tumor vaccines, to form a multi-level and multi-dimensional immunotherapy strategy, thus further enhancing the effect of immunotherapy. Multidisciplinary cooperation and integrated treatment can optimize the treatment plan and maximize the survival rate and quality of life of patients. Future research and clinical practice will further advance this field, promising more effective treatment options for patients with osteosarcoma. In this review, we reviewed metabolic and senescence characteristics in the immune microenvironment of osteosarcoma and related immunotherapies, and provide a reference for development of more personalized and effective therapeutic strategies. Frontiers Media S.A. 2023-07-11 /pmc/articles/PMC10366376/ /pubmed/37497349 http://dx.doi.org/10.3389/fendo.2023.1217669 Text en Copyright © 2023 Ying, Li, Li and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ying, Hui
Li, Zhi-Qiang
Li, Meng-Pan
Liu, Wen-Cai
Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title_full Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title_fullStr Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title_full_unstemmed Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title_short Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
title_sort metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366376/
https://www.ncbi.nlm.nih.gov/pubmed/37497349
http://dx.doi.org/10.3389/fendo.2023.1217669
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