Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humans

BACKGROUND: Poor translation between in vitro and clinical studies due to the cells/humans discrepancy in drug target perturbation effects leads to safety failures in clinical trials, thus increasing drug development costs and reducing patients’ life quality. Therefore, developing a predictive model...

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Detalles Bibliográficos
Autores principales: Park, Minhyuk, Kim, Donghyo, Kim, Inhae, Im, Sin-Hyeog, Kim, Sanguk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366401/
https://www.ncbi.nlm.nih.gov/pubmed/37453362
http://dx.doi.org/10.1016/j.ebiom.2023.104705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366401/
https://www.ncbi.nlm.nih.gov/pubmed/37453362
http://dx.doi.org/10.1016/j.ebiom.2023.104705

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