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Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humans
BACKGROUND: Poor translation between in vitro and clinical studies due to the cells/humans discrepancy in drug target perturbation effects leads to safety failures in clinical trials, thus increasing drug development costs and reducing patients’ life quality. Therefore, developing a predictive model...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366401/ https://www.ncbi.nlm.nih.gov/pubmed/37453362 http://dx.doi.org/10.1016/j.ebiom.2023.104705 |