Cargando…

Machine Learning-Based Proteomics Reveals Ferroptosis in COPD Patient-Derived Airway Epithelial Cells Upon Smoking Exposure

BACKGROUND: Proteomics and genomics studies have contributed to understanding the pathogenesis of chronic obstructive pulmonary disease (COPD), but previous studies have limitations. Here, using a machine learning (ML) algorithm, we attempted to identify pathways in cultured bronchial epithelial cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoon, Jung-Ki, Park, Sungjoon, Lee, Kyoung-Hee, Jeong, Dabin, Woo, Jisu, Park, Jieun, Yi, Seung-Muk, Han, Dohyun, Yoo, Chul-Gyu, Kim, Sun, Lee, Chang-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Academy of Medical Sciences 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366413/ https://www.ncbi.nlm.nih.gov/pubmed/37489716 http://dx.doi.org/10.3346/jkms.2023.38.e220

Ejemplares similares

The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
por: Park, Jieun, et al.
Publicado: (2021)

Downregulation of Lysosome-Associated Membrane Protein-2A Contributes to the Pathogenesis of COPD
por: Jeong, Yun-Jeong, et al.
Publicado: (2023)

YPL-001 Shows Various Beneficial Effects against Cigarette Smoke Extract-Induced Emphysema Formation: Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Effects
por: Lee, Kyoung-Hee, et al.
Publicado: (2022)

Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells
por: Lee, Kyoung-Hee, et al.
Publicado: (2018)

Cigarette Smoke Extract Enhances IL-17A-Induced IL-8 Production via Up-Regulation of IL-17R in Human Bronchial Epithelial Cells
por: Lee, Kyoung-Hee, et al.
Publicado: (2018)

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
por: Yoshida, Masahiro, et al.
Publicado: (2019)

Myofibroblast expression in airways and alveoli is affected by smoking and COPD
por: Karvonen, Henna M, et al.
Publicado: (2013)

Difference in systemic inflammation and predictors of acute exacerbation between smoking-associated COPD and tuberculosis-associated COPD
por: Oh, Jee Youn, et al.
Publicado: (2018)

Proteasome Inhibitor-Induced IκB/NF-κB Activation is Mediated by Nrf2-Dependent Light Chain 3B Induction in Lung Cancer Cells
por: Lee, Kyoung-Hee, et al.
Publicado: (2018)

The Impact of Autophagy on the Cigarette Smoke Extract-Induced Apoptosis of Bronchial Epithelial Cells
por: Lee, Chang-Hoon, et al.
Publicado: (2017)

Genome-wide assessment of gene-by-smoking interactions in COPD
por: Park, Boram, et al.
Publicado: (2018)

Globular Adiponectin Exerts a Pro-Inflammatory Effect via IκB/NF-κB Pathway Activation and Anti-Inflammatory Effect by IRAK-1 Downregulation
por: Lee, Kyoung-Hee, et al.
Publicado: (2018)

Dual Oxidase 2 (DUOX2) as a Proteomic Biomarker for Predicting Treatment Response to Chemoradiation Therapy for Locally Advanced Rectal Cancer: Using High-Throughput Proteomic Analysis and Machine Learning Algorithm
por: Lee, Hyebin, et al.
Publicado: (2022)

Outcome of Smoking Cessation on Airway Remodeling and Pulmonary Inflammation in COPD Patients
por: Mortaz, Esmaeil, et al.
Publicado: (2011)

Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD
por: Stoll, Paul, et al.
Publicado: (2014)

Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls
por: Ishikawa, Nobuhisa, et al.
Publicado: (2015)

Susceptibility to COPD: Differential Proteomic Profiling after Acute Smoking
por: Franciosi, Lorenza, et al.
Publicado: (2014)

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
por: Park, Tae-Jun, et al.
Publicado: (2019)

Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of Smoking?
por: Kato, Akane, et al.
Publicado: (2016)

Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
por: Lee, Chang-Hoon, et al.
Publicado: (2015)

Analysis of the proteome of human airway epithelial secretions
por: Ali, Mehboob, et al.
Publicado: (2011)

Comparison of COPD Assessment Test and Clinical COPD Questionnaire to predict the risk of exacerbation
por: Jo, Yong Suk, et al.
Publicado: (2017)

Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice
por: Seys, Leen J. M., et al.
Publicado: (2015)

Small airway imaging phenotypes in biomass- and tobacco smoke-exposed patients with COPD
por: Fernandes, Lalita, et al.
Publicado: (2017)

Synergistic cycles of protease activity and inflammation via PPARγ degradation in chronic obstructive pulmonary disease
por: Kwak, Nakwon, et al.
Publicado: (2021)

Clinical Outcome of Eosinophilic Airway Inflammation in Chronic Airway Diseases Including Nonasthmatic Eosinophilic Bronchitis
por: Cho, Jaeyoung, et al.
Publicado: (2018)

Smoking induces sex-specific changes in the small airway proteome
por: Kokelj, Spela, et al.
Publicado: (2021)

Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort
por: Park, Hye Jung, et al.
Publicado: (2017)

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution
por: Yeo, Sooho, et al.
Publicado: (2020)

The molecular mechanism of ferroptosis and its role in COPD
por: Meng, Dandan, et al.
Publicado: (2023)

Ferroptosis triggers airway inflammation in asthma
por: Li, Minming, et al.
Publicado: (2023)

Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease
por: Joo, Dong-Hyun, et al.
Publicado: (2021)

Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
por: Park, Heemoon, et al.
Publicado: (2022)

Blood lead levels in relation to smoking and chronic obstructive pulmonary disease (COPD): a study from Korean National Health and Nutrition Examination Survey (KNHANES)
por: Lee, Eunyoung, et al.
Publicado: (2020)

Effects of Air Pollutants on Airway Diseases
por: Lee, Yun-Gi, et al.
Publicado: (2021)

Effects of Disease Detection on Changes in Smoking Behavior
por: Kwon, Jeoung A, et al.
Publicado: (2015)

Age-related annual decline of lung function in patients with COPD
por: Kim, Soo Jung, et al.
Publicado: (2015)

Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD
por: Zhang, Ming, et al.
Publicado: (2020)

DRIM: A Web-Based System for Investigating Drug Response at the Molecular Level by Condition-Specific Multi-Omics Data Integration
por: Oh, Minsik, et al.
Publicado: (2020)

Longitudinal comparison of outcomes in patients with smoking-related asthma-COPD overlap and in non-smoking asthmatics with incomplete reversibility of airway obstruction
por: Boulet, Louis-Philippe, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_itl7h1spqjpe6vuqmddsd8q80h