Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia

Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in the circulation in patients during infection. Here, we comb...

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Detalles Bibliográficos
Autores principales: Schuurman, Alex R., Butler, Joe M., Michels, Erik H.A., Otto, Natasja A., Brands, Xanthe, Haak, Bastiaan W., Uhel, Fabrice, Klarenbeek, Augustijn M., Faber, Daniël R., Schomakers, Bauke V., van Weeghel, Michel, de Vos, Alex F., Scicluna, Brendon P., Houtkooper, Riekelt H., Wiersinga, W. Joost, van der Poll, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366455/
https://www.ncbi.nlm.nih.gov/pubmed/37496676
http://dx.doi.org/10.1016/j.isci.2023.107181

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