Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming

Histone deacetylases enzymes (HDACs) are chromatin modifiers that regulate gene expression through deacetylation of lysine residues within specific histone and non-histone proteins. A cell-specific gene expression pattern defines the identity of insulin-producing pancreatic β cells, yet molecular ne...

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Detalles Bibliográficos
Autores principales: Oger, Frédérik, Moreno, Maeva, Derhourhi, Mehdi, Thiroux, Bryan, Berberian, Lionel, Bourouh, Cyril, Durand, Emmanuelle, Amanzougarene, Souhila, Badreddine, Alaa, Blanc, Etienne, Molendi-Coste, Olivier, Pineau, Laurent, Pasquetti, Gianni, Rolland, Laure, Carney, Charlène, Bornaque, Florine, Courty, Emilie, Gheeraert, Céline, Eeckhoute, Jérôme, Dombrowicz, David, Kerr-Conte, Julie, Pattou, François, Staels, Bart, Froguel, Philippe, Bonnefond, Amélie, Annicotte, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366467/
https://www.ncbi.nlm.nih.gov/pubmed/37496675
http://dx.doi.org/10.1016/j.isci.2023.107231

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