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Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma

OBJECTIVE: The presence of cervical lymph node metastases (CLNM) at diagnosis is one of the most relevant negative prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). The aim of this study was to analyse 2-deoxy-2[(18)F]fluoro-D-glucose (FDG) PET/CT findings for the id...

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Autores principales: Bianchini, Chiara, Caracciolo, Matteo, Urso, Luca, Ciorba, Andrea, Bonsembiante, Anna, Migliorelli, Andrea, Corazzi, Virginia, Carandina, Ilaria, Ortolan, Naima, Cittanti, Corrado, Uccelli, Licia, Pelucchi, Stefano, Panareo, Stefano, Bartolomei, Mirco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366561/
https://www.ncbi.nlm.nih.gov/pubmed/37224172
http://dx.doi.org/10.14639/0392-100X-N2370
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author Bianchini, Chiara
Caracciolo, Matteo
Urso, Luca
Ciorba, Andrea
Bonsembiante, Anna
Migliorelli, Andrea
Corazzi, Virginia
Carandina, Ilaria
Ortolan, Naima
Cittanti, Corrado
Uccelli, Licia
Pelucchi, Stefano
Panareo, Stefano
Bartolomei, Mirco
author_facet Bianchini, Chiara
Caracciolo, Matteo
Urso, Luca
Ciorba, Andrea
Bonsembiante, Anna
Migliorelli, Andrea
Corazzi, Virginia
Carandina, Ilaria
Ortolan, Naima
Cittanti, Corrado
Uccelli, Licia
Pelucchi, Stefano
Panareo, Stefano
Bartolomei, Mirco
author_sort Bianchini, Chiara
collection PubMed
description OBJECTIVE: The presence of cervical lymph node metastases (CLNM) at diagnosis is one of the most relevant negative prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). The aim of this study was to analyse 2-deoxy-2[(18)F]fluoro-D-glucose (FDG) PET/CT findings for the identification of primary tumours and CLNM in a sample of patients affected by HNSCC. Moreover, a maximum standardised uptake value (SUVmax) threshold for the detection of CLNM was estimated. Clinical variables (i.e. smoking and alcohol habits), and tumour features (i.e. EBV and HPV positivity) were also evaluated in relation to FDG PET/CT findings. METHODS: We retrospectively analysed patients who underwent FDG PET/CT for HNSCC staging between 2015-2020 at the University Hospital of Ferrara. All patients had cytological or histological confirmation of suspected cervical lymph nodes. RESULTS: In total, 65 patients were enrolled (53 males, 12 females, median age 65.7 years). CLNM of patients with smoking habit had significantly higher SUVmax values than those of patients with previous smoking habit and non-smokers (p = 0.04). p16 positive HNSCC demonstrated a trend for higher SUVmax values on CLNM, in comparison to p16 negative tumours (p = 0.089). ROC curve analysis identified 5.8 as the best cut-off value of SUVmax for the detection of CLNM (AUC = 0.62, sensitivity 71.4% and specificity 72.7%). CONCLUSIONS: FDG PET/CT is a useful tool to evaluate CLNM in patients with HNSCC, particularly in those with smoking habit and p16 positive disease. A SUVmax cut-off of 5.8, combined with the use of conventional radiological investigations, may represent a useful tool in the identification of CLNM.
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spelling pubmed-103665612023-08-01 Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma Bianchini, Chiara Caracciolo, Matteo Urso, Luca Ciorba, Andrea Bonsembiante, Anna Migliorelli, Andrea Corazzi, Virginia Carandina, Ilaria Ortolan, Naima Cittanti, Corrado Uccelli, Licia Pelucchi, Stefano Panareo, Stefano Bartolomei, Mirco Acta Otorhinolaryngol Ital Head and Neck OBJECTIVE: The presence of cervical lymph node metastases (CLNM) at diagnosis is one of the most relevant negative prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). The aim of this study was to analyse 2-deoxy-2[(18)F]fluoro-D-glucose (FDG) PET/CT findings for the identification of primary tumours and CLNM in a sample of patients affected by HNSCC. Moreover, a maximum standardised uptake value (SUVmax) threshold for the detection of CLNM was estimated. Clinical variables (i.e. smoking and alcohol habits), and tumour features (i.e. EBV and HPV positivity) were also evaluated in relation to FDG PET/CT findings. METHODS: We retrospectively analysed patients who underwent FDG PET/CT for HNSCC staging between 2015-2020 at the University Hospital of Ferrara. All patients had cytological or histological confirmation of suspected cervical lymph nodes. RESULTS: In total, 65 patients were enrolled (53 males, 12 females, median age 65.7 years). CLNM of patients with smoking habit had significantly higher SUVmax values than those of patients with previous smoking habit and non-smokers (p = 0.04). p16 positive HNSCC demonstrated a trend for higher SUVmax values on CLNM, in comparison to p16 negative tumours (p = 0.089). ROC curve analysis identified 5.8 as the best cut-off value of SUVmax for the detection of CLNM (AUC = 0.62, sensitivity 71.4% and specificity 72.7%). CONCLUSIONS: FDG PET/CT is a useful tool to evaluate CLNM in patients with HNSCC, particularly in those with smoking habit and p16 positive disease. A SUVmax cut-off of 5.8, combined with the use of conventional radiological investigations, may represent a useful tool in the identification of CLNM. Pacini Editore Srl 2023-08-01 2023-08 /pmc/articles/PMC10366561/ /pubmed/37224172 http://dx.doi.org/10.14639/0392-100X-N2370 Text en Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Head and Neck
Bianchini, Chiara
Caracciolo, Matteo
Urso, Luca
Ciorba, Andrea
Bonsembiante, Anna
Migliorelli, Andrea
Corazzi, Virginia
Carandina, Ilaria
Ortolan, Naima
Cittanti, Corrado
Uccelli, Licia
Pelucchi, Stefano
Panareo, Stefano
Bartolomei, Mirco
Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title_full Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title_fullStr Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title_full_unstemmed Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title_short Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma
title_sort role of 18f-fdg pet/ct in evaluating lymph node status in patients with head and neck squamous cell carcinoma
topic Head and Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366561/
https://www.ncbi.nlm.nih.gov/pubmed/37224172
http://dx.doi.org/10.14639/0392-100X-N2370
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