Cargando…

Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment

Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Xinyi, Yin, Jin, Wang, Di, Huang, Erjiong, Zhang, Yini, Yin, Jiani C., Huang, Chen, Wu, Hao, Wu, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366596/
https://www.ncbi.nlm.nih.gov/pubmed/37496667
http://dx.doi.org/10.3389/fonc.2023.1195837
_version_ 1785077201571414016
author Shao, Xinyi
Yin, Jin
Wang, Di
Huang, Erjiong
Zhang, Yini
Yin, Jiani C.
Huang, Chen
Wu, Hao
Wu, Xiaoli
author_facet Shao, Xinyi
Yin, Jin
Wang, Di
Huang, Erjiong
Zhang, Yini
Yin, Jiani C.
Huang, Chen
Wu, Hao
Wu, Xiaoli
author_sort Shao, Xinyi
collection PubMed
description Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non-gastric tumors. At present, the incidence of SMGC is low in China, with no established guidelines for standard treatment. Here, we report a rare case of advanced SMGC that achieved long-lasting clinical benefits through a treatment strategy informed by next-generation sequencing (NGS). Dynamically monitoring of the tumor and/or circulating cell-free DNA guided the patient’s treatment sequentially. The patient received anti-HER2 therapy, followed by immunotherapy, pembrolizumab in combination with trastuzumab and chemotherapy, and ultimately underwent successful total gastrectomy. This case highlights a novel approach of utilizing liquid biopsy-based NGS to gain insights into disease progression and molecular response to NGS-guided treatment in SMGC patients.
format Online
Article
Text
id pubmed-10366596
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103665962023-07-26 Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment Shao, Xinyi Yin, Jin Wang, Di Huang, Erjiong Zhang, Yini Yin, Jiani C. Huang, Chen Wu, Hao Wu, Xiaoli Front Oncol Oncology Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non-gastric tumors. At present, the incidence of SMGC is low in China, with no established guidelines for standard treatment. Here, we report a rare case of advanced SMGC that achieved long-lasting clinical benefits through a treatment strategy informed by next-generation sequencing (NGS). Dynamically monitoring of the tumor and/or circulating cell-free DNA guided the patient’s treatment sequentially. The patient received anti-HER2 therapy, followed by immunotherapy, pembrolizumab in combination with trastuzumab and chemotherapy, and ultimately underwent successful total gastrectomy. This case highlights a novel approach of utilizing liquid biopsy-based NGS to gain insights into disease progression and molecular response to NGS-guided treatment in SMGC patients. Frontiers Media S.A. 2023-07-11 /pmc/articles/PMC10366596/ /pubmed/37496667 http://dx.doi.org/10.3389/fonc.2023.1195837 Text en Copyright © 2023 Shao, Yin, Wang, Huang, Zhang, Yin, Huang, Wu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shao, Xinyi
Yin, Jin
Wang, Di
Huang, Erjiong
Zhang, Yini
Yin, Jiani C.
Huang, Chen
Wu, Hao
Wu, Xiaoli
Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title_full Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title_fullStr Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title_full_unstemmed Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title_short Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
title_sort case report: a rare synchronous multiple gastric carcinoma achieved progression-free disease through ngs-guided serial treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366596/
https://www.ncbi.nlm.nih.gov/pubmed/37496667
http://dx.doi.org/10.3389/fonc.2023.1195837
work_keys_str_mv AT shaoxinyi casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT yinjin casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT wangdi casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT huangerjiong casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT zhangyini casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT yinjianic casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT huangchen casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT wuhao casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment
AT wuxiaoli casereportararesynchronousmultiplegastriccarcinomaachievedprogressionfreediseasethroughngsguidedserialtreatment