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Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366596/ https://www.ncbi.nlm.nih.gov/pubmed/37496667 http://dx.doi.org/10.3389/fonc.2023.1195837 |
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author | Shao, Xinyi Yin, Jin Wang, Di Huang, Erjiong Zhang, Yini Yin, Jiani C. Huang, Chen Wu, Hao Wu, Xiaoli |
author_facet | Shao, Xinyi Yin, Jin Wang, Di Huang, Erjiong Zhang, Yini Yin, Jiani C. Huang, Chen Wu, Hao Wu, Xiaoli |
author_sort | Shao, Xinyi |
collection | PubMed |
description | Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non-gastric tumors. At present, the incidence of SMGC is low in China, with no established guidelines for standard treatment. Here, we report a rare case of advanced SMGC that achieved long-lasting clinical benefits through a treatment strategy informed by next-generation sequencing (NGS). Dynamically monitoring of the tumor and/or circulating cell-free DNA guided the patient’s treatment sequentially. The patient received anti-HER2 therapy, followed by immunotherapy, pembrolizumab in combination with trastuzumab and chemotherapy, and ultimately underwent successful total gastrectomy. This case highlights a novel approach of utilizing liquid biopsy-based NGS to gain insights into disease progression and molecular response to NGS-guided treatment in SMGC patients. |
format | Online Article Text |
id | pubmed-10366596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103665962023-07-26 Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment Shao, Xinyi Yin, Jin Wang, Di Huang, Erjiong Zhang, Yini Yin, Jiani C. Huang, Chen Wu, Hao Wu, Xiaoli Front Oncol Oncology Synchronous multiple gastric carcinoma (SMGC) is a rare condition characterized by the simultaneous occurrence of two or more primary malignant tumors in the stomach, each with its own distinct pathological morphology. SMGC differs from gastric metastases, which originate from primary gastric or non-gastric tumors. At present, the incidence of SMGC is low in China, with no established guidelines for standard treatment. Here, we report a rare case of advanced SMGC that achieved long-lasting clinical benefits through a treatment strategy informed by next-generation sequencing (NGS). Dynamically monitoring of the tumor and/or circulating cell-free DNA guided the patient’s treatment sequentially. The patient received anti-HER2 therapy, followed by immunotherapy, pembrolizumab in combination with trastuzumab and chemotherapy, and ultimately underwent successful total gastrectomy. This case highlights a novel approach of utilizing liquid biopsy-based NGS to gain insights into disease progression and molecular response to NGS-guided treatment in SMGC patients. Frontiers Media S.A. 2023-07-11 /pmc/articles/PMC10366596/ /pubmed/37496667 http://dx.doi.org/10.3389/fonc.2023.1195837 Text en Copyright © 2023 Shao, Yin, Wang, Huang, Zhang, Yin, Huang, Wu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shao, Xinyi Yin, Jin Wang, Di Huang, Erjiong Zhang, Yini Yin, Jiani C. Huang, Chen Wu, Hao Wu, Xiaoli Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title | Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title_full | Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title_fullStr | Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title_full_unstemmed | Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title_short | Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment |
title_sort | case report: a rare synchronous multiple gastric carcinoma achieved progression-free disease through ngs-guided serial treatment |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366596/ https://www.ncbi.nlm.nih.gov/pubmed/37496667 http://dx.doi.org/10.3389/fonc.2023.1195837 |
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