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Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms

Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on da...

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Autores principales: Alvarez-Rivera, Eduardo, Ortiz-Hernández, Emanuel J., Lugo, Elyette, Lozada-Reyes, Lorraine M., Boukli, Nawal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366845/
https://www.ncbi.nlm.nih.gov/pubmed/37489388
http://dx.doi.org/10.3390/proteomes11030022
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author Alvarez-Rivera, Eduardo
Ortiz-Hernández, Emanuel J.
Lugo, Elyette
Lozada-Reyes, Lorraine M.
Boukli, Nawal M.
author_facet Alvarez-Rivera, Eduardo
Ortiz-Hernández, Emanuel J.
Lugo, Elyette
Lozada-Reyes, Lorraine M.
Boukli, Nawal M.
author_sort Alvarez-Rivera, Eduardo
collection PubMed
description Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART.
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spelling pubmed-103668452023-07-26 Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms Alvarez-Rivera, Eduardo Ortiz-Hernández, Emanuel J. Lugo, Elyette Lozada-Reyes, Lorraine M. Boukli, Nawal M. Proteomes Review Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART. MDPI 2023-07-04 /pmc/articles/PMC10366845/ /pubmed/37489388 http://dx.doi.org/10.3390/proteomes11030022 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alvarez-Rivera, Eduardo
Ortiz-Hernández, Emanuel J.
Lugo, Elyette
Lozada-Reyes, Lorraine M.
Boukli, Nawal M.
Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title_full Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title_fullStr Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title_full_unstemmed Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title_short Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
title_sort oncogenic proteomics approaches for translational research and hiv-associated malignancy mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366845/
https://www.ncbi.nlm.nih.gov/pubmed/37489388
http://dx.doi.org/10.3390/proteomes11030022
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