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Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms
Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on da...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366845/ https://www.ncbi.nlm.nih.gov/pubmed/37489388 http://dx.doi.org/10.3390/proteomes11030022 |
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author | Alvarez-Rivera, Eduardo Ortiz-Hernández, Emanuel J. Lugo, Elyette Lozada-Reyes, Lorraine M. Boukli, Nawal M. |
author_facet | Alvarez-Rivera, Eduardo Ortiz-Hernández, Emanuel J. Lugo, Elyette Lozada-Reyes, Lorraine M. Boukli, Nawal M. |
author_sort | Alvarez-Rivera, Eduardo |
collection | PubMed |
description | Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART. |
format | Online Article Text |
id | pubmed-10366845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103668452023-07-26 Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms Alvarez-Rivera, Eduardo Ortiz-Hernández, Emanuel J. Lugo, Elyette Lozada-Reyes, Lorraine M. Boukli, Nawal M. Proteomes Review Recent advances in the field of proteomics have allowed extensive insights into the molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a multitude of signaling arrays while targeting for the discovery of novel protein signatures. These approaches based on data mining are becoming increasingly powerful for identifying both potential disease mechanisms as well as indicators for disease progression and overall survival predictive and prognostic molecular markers for cancer. Furthermore, mass spectrometry (MS) integrations satisfy the ongoing demand for in-depth biomarker validation. For the purpose of this review, we will highlight the current developments based on MS sensitivity, to place quantitative proteomics into clinical settings and provide a perspective to integrate proteomics data for future applications in cancer precision medicine. We will also discuss malignancies associated with oncogenic viruses such as Acquire Immunodeficiency Syndrome (AIDS) and suggest novel mechanisms behind this phenomenon. Human Immunodeficiency Virus type-1 (HIV-1) proteins are known to be oncogenic per se, to induce oxidative and endoplasmic reticulum stresses, and to be released from the infected or expressing cells. HIV-1 proteins can act alone or in collaboration with other known oncoproteins, which cause the bulk of malignancies in people living with HIV-1 on ART. MDPI 2023-07-04 /pmc/articles/PMC10366845/ /pubmed/37489388 http://dx.doi.org/10.3390/proteomes11030022 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alvarez-Rivera, Eduardo Ortiz-Hernández, Emanuel J. Lugo, Elyette Lozada-Reyes, Lorraine M. Boukli, Nawal M. Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title_full | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title_fullStr | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title_full_unstemmed | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title_short | Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms |
title_sort | oncogenic proteomics approaches for translational research and hiv-associated malignancy mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366845/ https://www.ncbi.nlm.nih.gov/pubmed/37489388 http://dx.doi.org/10.3390/proteomes11030022 |
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