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Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study

(1) Background: Oncological demolitive–reconstructive surgeries in the head and neck region cause significant stress on patients’ biohumoural, cardiac, and vascular systems, leading to disturbances in macrocirculatory and microcirculatory parameters. Traditional monitoring addresses the symptoms, bu...

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Autores principales: Adembri, Chiara, Ungar, Andrea, Cappellini, Iacopo, Romano, Salvatore Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366866/
https://www.ncbi.nlm.nih.gov/pubmed/37489434
http://dx.doi.org/10.3390/mps6040067
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author Adembri, Chiara
Ungar, Andrea
Cappellini, Iacopo
Romano, Salvatore Mario
author_facet Adembri, Chiara
Ungar, Andrea
Cappellini, Iacopo
Romano, Salvatore Mario
author_sort Adembri, Chiara
collection PubMed
description (1) Background: Oncological demolitive–reconstructive surgeries in the head and neck region cause significant stress on patients’ biohumoural, cardiac, and vascular systems, leading to disturbances in macrocirculatory and microcirculatory parameters. Traditional monitoring addresses the symptoms, but not the underlying cause. Microcirculatory assessments complement macrocirculatory monitoring, and bladder-catheter-based technology offers a better representation of central microcirculation. Flap reconstruction surgeries involve demolitive and reconstructive phases, requiring optimal tissue perfusion. The literature lacks a consensus on macro–microcirculation coupling, and there is no agreement on the use of vasopressors during head and neck surgeries. Evidence-based guidelines are lacking, resulting in variations in vasopressor administration. (2) Methods: This is a 12-month observational, prospective study conducted in a single center. It aims to evaluate the impact of macro–microcirculation coupling on clinical complications in head and neck surgery. All consecutive patients undergoing oncologic surgery requiring flap reconstruction and meeting the inclusion criteria will be enrolled. The study will utilize standard hemodynamic monitoring and bladder catheterization for measuring urine output and temperature. (3) Conclusions: The study aims to evaluate the coupling of macro- and microcirculation in head and neck surgeries, assess hemodynamic parameters and microcirculatory changes, and investigate their association with postoperative complications. The results can enhance patient care and surgical outcomes.
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spelling pubmed-103668662023-07-26 Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study Adembri, Chiara Ungar, Andrea Cappellini, Iacopo Romano, Salvatore Mario Methods Protoc Protocol (1) Background: Oncological demolitive–reconstructive surgeries in the head and neck region cause significant stress on patients’ biohumoural, cardiac, and vascular systems, leading to disturbances in macrocirculatory and microcirculatory parameters. Traditional monitoring addresses the symptoms, but not the underlying cause. Microcirculatory assessments complement macrocirculatory monitoring, and bladder-catheter-based technology offers a better representation of central microcirculation. Flap reconstruction surgeries involve demolitive and reconstructive phases, requiring optimal tissue perfusion. The literature lacks a consensus on macro–microcirculation coupling, and there is no agreement on the use of vasopressors during head and neck surgeries. Evidence-based guidelines are lacking, resulting in variations in vasopressor administration. (2) Methods: This is a 12-month observational, prospective study conducted in a single center. It aims to evaluate the impact of macro–microcirculation coupling on clinical complications in head and neck surgery. All consecutive patients undergoing oncologic surgery requiring flap reconstruction and meeting the inclusion criteria will be enrolled. The study will utilize standard hemodynamic monitoring and bladder catheterization for measuring urine output and temperature. (3) Conclusions: The study aims to evaluate the coupling of macro- and microcirculation in head and neck surgeries, assess hemodynamic parameters and microcirculatory changes, and investigate their association with postoperative complications. The results can enhance patient care and surgical outcomes. MDPI 2023-07-21 /pmc/articles/PMC10366866/ /pubmed/37489434 http://dx.doi.org/10.3390/mps6040067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Adembri, Chiara
Ungar, Andrea
Cappellini, Iacopo
Romano, Salvatore Mario
Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title_full Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title_fullStr Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title_full_unstemmed Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title_short Variations in Microcirculatory and Hemodynamic Parameters during Oncological Demolitive–Reconstructive Head and Neck Surgery: A Protocol for an Observational Study
title_sort variations in microcirculatory and hemodynamic parameters during oncological demolitive–reconstructive head and neck surgery: a protocol for an observational study
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366866/
https://www.ncbi.nlm.nih.gov/pubmed/37489434
http://dx.doi.org/10.3390/mps6040067
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