Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease

As of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the...

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Autores principales: Doher, Nicholas, Davoudi, Vahid, Magaki, Shino, Townley, Ryan A., Haeri, Mohammad, Vinters, Harry V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366902/
https://www.ncbi.nlm.nih.gov/pubmed/37489360
http://dx.doi.org/10.3390/neurolint15030054
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author Doher, Nicholas
Davoudi, Vahid
Magaki, Shino
Townley, Ryan A.
Haeri, Mohammad
Vinters, Harry V.
author_facet Doher, Nicholas
Davoudi, Vahid
Magaki, Shino
Townley, Ryan A.
Haeri, Mohammad
Vinters, Harry V.
author_sort Doher, Nicholas
collection PubMed
description As of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the underlying mechanisms in AD. The current method for assessing postmortem Alzheimer’s disease neuropathologic change follows version 11 of the National Alzheimer’s Coordinating Center (NACC) coding guidebook. Ambiguity regarding steps in the ABC scoring method can lead to increased time or inaccuracy in staging AD. We present a concise overview of how this postmortem diagnosis is made and relate it to the evolving understanding of antemortem AD biomarkers.
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spelling pubmed-103669022023-07-26 Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease Doher, Nicholas Davoudi, Vahid Magaki, Shino Townley, Ryan A. Haeri, Mohammad Vinters, Harry V. Neurol Int Opinion As of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the underlying mechanisms in AD. The current method for assessing postmortem Alzheimer’s disease neuropathologic change follows version 11 of the National Alzheimer’s Coordinating Center (NACC) coding guidebook. Ambiguity regarding steps in the ABC scoring method can lead to increased time or inaccuracy in staging AD. We present a concise overview of how this postmortem diagnosis is made and relate it to the evolving understanding of antemortem AD biomarkers. MDPI 2023-07-12 /pmc/articles/PMC10366902/ /pubmed/37489360 http://dx.doi.org/10.3390/neurolint15030054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Doher, Nicholas
Davoudi, Vahid
Magaki, Shino
Townley, Ryan A.
Haeri, Mohammad
Vinters, Harry V.
Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title_full Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title_fullStr Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title_full_unstemmed Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title_short Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
title_sort illustrated neuropathologic diagnosis of alzheimer’s disease
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366902/
https://www.ncbi.nlm.nih.gov/pubmed/37489360
http://dx.doi.org/10.3390/neurolint15030054
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