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Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature

Hereditary platelet delta (δ)-storage pool deficiency is a rare condition in which there are fewer dense granules in platelets disrupting primary hemostasis. It can cause a mild–moderate bleeding tendency with normal coagulation studies; hence, it is an underdiagnosed diagnostic challenge. The autho...

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Detalles Bibliográficos
Autores principales: Beirat, Amir F., Menakuru, Sasmith R., Kalra, Maitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366910/
https://www.ncbi.nlm.nih.gov/pubmed/37489371
http://dx.doi.org/10.3390/hematolrep15030041
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author Beirat, Amir F.
Menakuru, Sasmith R.
Kalra, Maitri
author_facet Beirat, Amir F.
Menakuru, Sasmith R.
Kalra, Maitri
author_sort Beirat, Amir F.
collection PubMed
description Hereditary platelet delta (δ)-storage pool deficiency is a rare condition in which there are fewer dense granules in platelets disrupting primary hemostasis. It can cause a mild–moderate bleeding tendency with normal coagulation studies; hence, it is an underdiagnosed diagnostic challenge. The authors present three patients with hereditary platelet delta (δ)-storage pool deficiency who had heavy menstrual bleeding, excessive bleeding following surgery, mucocutaneous bleeding, and a bleeding score greater than or equal to 6. These cases reveal the susceptibility of underdiagnosing platelet disorders and the significance of utilizing a bleeding assessment tool to help guide further workup with transmission electron microscopy to visualize the fewer dense granules in platelets. Although bleeding is typically moderate, it can be severe in certain scenarios, like after mucosal surgeries, and can lead to death, highlighting the importance of the condition’s recognition and prophylactic treatment.
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spelling pubmed-103669102023-07-26 Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature Beirat, Amir F. Menakuru, Sasmith R. Kalra, Maitri Hematol Rep Case Report Hereditary platelet delta (δ)-storage pool deficiency is a rare condition in which there are fewer dense granules in platelets disrupting primary hemostasis. It can cause a mild–moderate bleeding tendency with normal coagulation studies; hence, it is an underdiagnosed diagnostic challenge. The authors present three patients with hereditary platelet delta (δ)-storage pool deficiency who had heavy menstrual bleeding, excessive bleeding following surgery, mucocutaneous bleeding, and a bleeding score greater than or equal to 6. These cases reveal the susceptibility of underdiagnosing platelet disorders and the significance of utilizing a bleeding assessment tool to help guide further workup with transmission electron microscopy to visualize the fewer dense granules in platelets. Although bleeding is typically moderate, it can be severe in certain scenarios, like after mucosal surgeries, and can lead to death, highlighting the importance of the condition’s recognition and prophylactic treatment. MDPI 2023-06-29 /pmc/articles/PMC10366910/ /pubmed/37489371 http://dx.doi.org/10.3390/hematolrep15030041 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Beirat, Amir F.
Menakuru, Sasmith R.
Kalra, Maitri
Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title_full Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title_fullStr Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title_full_unstemmed Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title_short Platelet Delta (δ)-Storage Pool Deficiency: A Case Series and Review of the Literature
title_sort platelet delta (δ)-storage pool deficiency: a case series and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366910/
https://www.ncbi.nlm.nih.gov/pubmed/37489371
http://dx.doi.org/10.3390/hematolrep15030041
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