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Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents

Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hematologic and solid tumors. Based on the capacity of the compoun...

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Autores principales: Gallimore, Fallon, Fandy, Tamer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366911/
https://www.ncbi.nlm.nih.gov/pubmed/37489400
http://dx.doi.org/10.3390/epigenomes7030012
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author Gallimore, Fallon
Fandy, Tamer E.
author_facet Gallimore, Fallon
Fandy, Tamer E.
author_sort Gallimore, Fallon
collection PubMed
description Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hematologic and solid tumors. Based on the capacity of the compounds to inhibit DNA methyltransferase enzymes and the important role of DNA methylation in health and disease, it is essential to understand the molecular changes that azanucleosides induce and how these changes may improve treatment outcomes in subsets of patients. This review summarizes the molecular and therapeutic actions of azanucleosides and discusses recent clinical trials of these compounds as single agents or in combination therapy for the treatment of cancer and related conditions.
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spelling pubmed-103669112023-07-26 Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents Gallimore, Fallon Fandy, Tamer E. Epigenomes Review Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hematologic and solid tumors. Based on the capacity of the compounds to inhibit DNA methyltransferase enzymes and the important role of DNA methylation in health and disease, it is essential to understand the molecular changes that azanucleosides induce and how these changes may improve treatment outcomes in subsets of patients. This review summarizes the molecular and therapeutic actions of azanucleosides and discusses recent clinical trials of these compounds as single agents or in combination therapy for the treatment of cancer and related conditions. MDPI 2023-07-05 /pmc/articles/PMC10366911/ /pubmed/37489400 http://dx.doi.org/10.3390/epigenomes7030012 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gallimore, Fallon
Fandy, Tamer E.
Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title_full Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title_fullStr Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title_full_unstemmed Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title_short Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
title_sort therapeutic applications of azanucleoside analogs as dna demethylating agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366911/
https://www.ncbi.nlm.nih.gov/pubmed/37489400
http://dx.doi.org/10.3390/epigenomes7030012
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