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The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores

Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods:...

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Autores principales: Sacchetto, Luca, Monzani, Daniele, Apa, Enrico, Lovato, Andrea, Caragli, Valeria, Gherpelli, Chiara, Palma, Silvia, Genovese, Elisabetta, Nocini, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366923/
https://www.ncbi.nlm.nih.gov/pubmed/37489379
http://dx.doi.org/10.3390/audiolres13040043
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author Sacchetto, Luca
Monzani, Daniele
Apa, Enrico
Lovato, Andrea
Caragli, Valeria
Gherpelli, Chiara
Palma, Silvia
Genovese, Elisabetta
Nocini, Riccardo
author_facet Sacchetto, Luca
Monzani, Daniele
Apa, Enrico
Lovato, Andrea
Caragli, Valeria
Gherpelli, Chiara
Palma, Silvia
Genovese, Elisabetta
Nocini, Riccardo
author_sort Sacchetto, Luca
collection PubMed
description Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST.
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spelling pubmed-103669232023-07-26 The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores Sacchetto, Luca Monzani, Daniele Apa, Enrico Lovato, Andrea Caragli, Valeria Gherpelli, Chiara Palma, Silvia Genovese, Elisabetta Nocini, Riccardo Audiol Res Article Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST. MDPI 2023-07-07 /pmc/articles/PMC10366923/ /pubmed/37489379 http://dx.doi.org/10.3390/audiolres13040043 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sacchetto, Luca
Monzani, Daniele
Apa, Enrico
Lovato, Andrea
Caragli, Valeria
Gherpelli, Chiara
Palma, Silvia
Genovese, Elisabetta
Nocini, Riccardo
The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title_full The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title_fullStr The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title_full_unstemmed The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title_short The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
title_sort effect of alpha-lipoic acid in the treatment of chronic subjective tinnitus through the tinnitus handicap inventory scores
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366923/
https://www.ncbi.nlm.nih.gov/pubmed/37489379
http://dx.doi.org/10.3390/audiolres13040043
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