Cargando…
The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods:...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366923/ https://www.ncbi.nlm.nih.gov/pubmed/37489379 http://dx.doi.org/10.3390/audiolres13040043 |
_version_ | 1785077278802182144 |
---|---|
author | Sacchetto, Luca Monzani, Daniele Apa, Enrico Lovato, Andrea Caragli, Valeria Gherpelli, Chiara Palma, Silvia Genovese, Elisabetta Nocini, Riccardo |
author_facet | Sacchetto, Luca Monzani, Daniele Apa, Enrico Lovato, Andrea Caragli, Valeria Gherpelli, Chiara Palma, Silvia Genovese, Elisabetta Nocini, Riccardo |
author_sort | Sacchetto, Luca |
collection | PubMed |
description | Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST. |
format | Online Article Text |
id | pubmed-10366923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103669232023-07-26 The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores Sacchetto, Luca Monzani, Daniele Apa, Enrico Lovato, Andrea Caragli, Valeria Gherpelli, Chiara Palma, Silvia Genovese, Elisabetta Nocini, Riccardo Audiol Res Article Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST. MDPI 2023-07-07 /pmc/articles/PMC10366923/ /pubmed/37489379 http://dx.doi.org/10.3390/audiolres13040043 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sacchetto, Luca Monzani, Daniele Apa, Enrico Lovato, Andrea Caragli, Valeria Gherpelli, Chiara Palma, Silvia Genovese, Elisabetta Nocini, Riccardo The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title | The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title_full | The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title_fullStr | The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title_full_unstemmed | The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title_short | The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores |
title_sort | effect of alpha-lipoic acid in the treatment of chronic subjective tinnitus through the tinnitus handicap inventory scores |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366923/ https://www.ncbi.nlm.nih.gov/pubmed/37489379 http://dx.doi.org/10.3390/audiolres13040043 |
work_keys_str_mv | AT sacchettoluca theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT monzanidaniele theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT apaenrico theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT lovatoandrea theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT caraglivaleria theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT gherpellichiara theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT palmasilvia theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT genoveseelisabetta theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT nociniriccardo theeffectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT sacchettoluca effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT monzanidaniele effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT apaenrico effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT lovatoandrea effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT caraglivaleria effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT gherpellichiara effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT palmasilvia effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT genoveseelisabetta effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores AT nociniriccardo effectofalphalipoicacidinthetreatmentofchronicsubjectivetinnitusthroughthetinnitushandicapinventoryscores |