Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6)

[Image: see text] Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate zinc-binding group (ZBG). However, more recent work has shown that the use of alternative ZBGs, and, in particular, the heterocyclic oxadiazoles, can confer higher isoenzyme selectivity and mor...

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Detalles Bibliográficos
Autores principales: Motlová, Lucia, Šnajdr, Ivan, Kutil, Zsófia, Andris, Erik, Ptáček, Jakub, Novotná, Adéla, Nováková, Zora, Havlínová, Barbora, Tueckmantel, Werner, Dráberová, Helena, Majer, Pavel, Schutkowski, Mike, Kozikowski, Alan, Rulíšek, Lubomír, Bařinka, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367051/
https://www.ncbi.nlm.nih.gov/pubmed/37392419
http://dx.doi.org/10.1021/acschembio.3c00212

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