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Limiting the Loading of Reactant 1,3-Cyclohexanedione Enables the Use of Less Catalyst
[Image: see text] We demonstrated that the loading amounts and concentrations of reactant 1,3-cyclohexanedione affect reaction rates and outcomes. In certain cases, reactions with higher concentrations of 1,3-cyclohexanedione were slower than those with lower concentrations. By minimizing the use of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367063/ https://www.ncbi.nlm.nih.gov/pubmed/37403968 http://dx.doi.org/10.1021/acs.joc.3c00838 |
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author | Sohail, Muhammad Tanaka, Fujie |
author_facet | Sohail, Muhammad Tanaka, Fujie |
author_sort | Sohail, Muhammad |
collection | PubMed |
description | [Image: see text] We demonstrated that the loading amounts and concentrations of reactant 1,3-cyclohexanedione affect reaction rates and outcomes. In certain cases, reactions with higher concentrations of 1,3-cyclohexanedione were slower than those with lower concentrations. By minimizing the use of the cyclic 1,3-dione derivatives and by tuning the reaction concentration, the acid catalyst was reduced to 0.1 mol % to afford the desired products in high yields, and the reaction scope was expanded. |
format | Online Article Text |
id | pubmed-10367063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-103670632023-07-26 Limiting the Loading of Reactant 1,3-Cyclohexanedione Enables the Use of Less Catalyst Sohail, Muhammad Tanaka, Fujie J Org Chem [Image: see text] We demonstrated that the loading amounts and concentrations of reactant 1,3-cyclohexanedione affect reaction rates and outcomes. In certain cases, reactions with higher concentrations of 1,3-cyclohexanedione were slower than those with lower concentrations. By minimizing the use of the cyclic 1,3-dione derivatives and by tuning the reaction concentration, the acid catalyst was reduced to 0.1 mol % to afford the desired products in high yields, and the reaction scope was expanded. American Chemical Society 2023-07-05 /pmc/articles/PMC10367063/ /pubmed/37403968 http://dx.doi.org/10.1021/acs.joc.3c00838 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Sohail, Muhammad Tanaka, Fujie Limiting the Loading of Reactant 1,3-Cyclohexanedione Enables the Use of Less Catalyst |
title | Limiting the Loading
of Reactant 1,3-Cyclohexanedione
Enables the Use of Less Catalyst |
title_full | Limiting the Loading
of Reactant 1,3-Cyclohexanedione
Enables the Use of Less Catalyst |
title_fullStr | Limiting the Loading
of Reactant 1,3-Cyclohexanedione
Enables the Use of Less Catalyst |
title_full_unstemmed | Limiting the Loading
of Reactant 1,3-Cyclohexanedione
Enables the Use of Less Catalyst |
title_short | Limiting the Loading
of Reactant 1,3-Cyclohexanedione
Enables the Use of Less Catalyst |
title_sort | limiting the loading
of reactant 1,3-cyclohexanedione
enables the use of less catalyst |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367063/ https://www.ncbi.nlm.nih.gov/pubmed/37403968 http://dx.doi.org/10.1021/acs.joc.3c00838 |
work_keys_str_mv | AT sohailmuhammad limitingtheloadingofreactant13cyclohexanedioneenablestheuseoflesscatalyst AT tanakafujie limitingtheloadingofreactant13cyclohexanedioneenablestheuseoflesscatalyst |