Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides

[Image: see text] The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptide...

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Autores principales: Hernández, Dácil, Porras, Marina, Boto, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367070/
https://www.ncbi.nlm.nih.gov/pubmed/37429014
http://dx.doi.org/10.1021/acs.joc.3c00673
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author Hernández, Dácil
Porras, Marina
Boto, Alicia
author_facet Hernández, Dácil
Porras, Marina
Boto, Alicia
author_sort Hernández, Dácil
collection PubMed
description [Image: see text] The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptides with reversed sequences or with valuable turns.
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spelling pubmed-103670702023-07-26 Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides Hernández, Dácil Porras, Marina Boto, Alicia J Org Chem [Image: see text] The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptides with reversed sequences or with valuable turns. American Chemical Society 2023-07-10 /pmc/articles/PMC10367070/ /pubmed/37429014 http://dx.doi.org/10.1021/acs.joc.3c00673 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hernández, Dácil
Porras, Marina
Boto, Alicia
Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title_full Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title_fullStr Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title_full_unstemmed Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title_short Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides
title_sort conversion of hydroxyproline “doubly customizable units” to hexahydropyrimidines: access to conformationally constrained peptides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367070/
https://www.ncbi.nlm.nih.gov/pubmed/37429014
http://dx.doi.org/10.1021/acs.joc.3c00673
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AT botoalicia conversionofhydroxyprolinedoublycustomizableunitstohexahydropyrimidinesaccesstoconformationallyconstrainedpeptides

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