Cargando…

Conversion of Hydroxyproline “Doubly Customizable Units” to Hexahydropyrimidines: Access to Conformationally Constrained Peptides

[Image: see text] The efficient transformation of hydroxyproline “doubly customizable units” into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernández, Dácil, Porras, Marina, Boto, Alicia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367070/ https://www.ncbi.nlm.nih.gov/pubmed/37429014 http://dx.doi.org/10.1021/acs.joc.3c00673

Ejemplares similares

Structural diversity using amino acid “Customizable Units”: conversion of hydroxyproline (Hyp) into nitrogen heterocycles
por: Hernández, Dácil, et al.
Publicado: (2022)

“Cut and Paste” Processes in the Search of Bioactive Products: One-Pot, Metal-free O-Radical Scission-Oxidation-Addition of C, N or P-Nucleophiles
por: Porras, Marina, et al.
Publicado: (2022)

2-Phenyl-2-(pyridin-2-yl)hexahydropyrimidine
por: Jayaratna, Naleen B., et al.
Publicado: (2010)

Chemical Synthesis of Arabidopsis CLV3 Glycopeptide Reveals the Impact of Hydroxyproline Arabinosylation on Peptide Conformation and Activity
por: Shinohara, Hidefumi, et al.
Publicado: (2013)

2-Methyl-2-(2-pyridyl)hexahydropyrimidine
por: Al-Resayes, Saud
Publicado: (2009)

In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis
por: Martins, Francislene J., et al.
Publicado: (2017)

Doubly Constrained Waveform Optimization for Integrated Sensing and Communications
por: Ni, Zhitong, et al.
Publicado: (2023)

A new and efficient procedure for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones
por: Reis, Marcelo Isidoro P, et al.
Publicado: (2015)

Free serum hydroxyproline and total urinary hydroxyproline for the detection of skeletal metastasis.
por: Gasser, A. B., et al.
Publicado: (1982)

Mechanism of the Fe(iii)-catalyzed synthesis of hexahydropyrimidine with α-phenylstyrene: a DFT study
por: Cheng, Yaxuan, et al.
Publicado: (2022)

2-[2-Chloro-5-(trifluoromethyl)phenyl]hexahydropyrimidine monohydrate
por: Fun, Hoong-Kun, et al.
Publicado: (2008)

mu- conversion via doubly charged Higgs scalar
por: Picciotto, C E, et al.
Publicado: (1982)

Catalytic [2 + 2 + 2] cycloaddition with indium(iii)-activated formaldimines: a practical and selective access to hexahydropyrimidines and 1,3-diamines from alkenes
por: Zhou, Hui, et al.
Publicado: (2017)

Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
por: Honnegowda, Thittamaranahalli Muguregowda, et al.
Publicado: (2014)

Small and Simple, yet Sturdy: Conformationally Constrained Peptides with Remarkable Properties
por: Bozovičar, Krištof, et al.
Publicado: (2021)

Customizable, conformal, and stretchable 3D electronics via predistorted pattern generation and thermoforming
por: Choi, Jungrak, et al.
Publicado: (2021)

Prediction and Analysis of Protein Hydroxyproline and Hydroxylysine
por: Hu, Le-Le, et al.
Publicado: (2010)

THE SOLUBILITIES OF l-PROLINE AND l-HYDROXYPROLINE IN WATER, THE CALCULATED HEATS OF SOLUTION, AND THE PARTIAL MOLAL VOLUME OF l-HYDROXYPROLINE
por: Tomiyama, Tetuo, et al.
Publicado: (1935)

Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization
por: Pathak, Pragya, et al.
Publicado: (2023)

TBS-pyrrole as an “universal” reference to quantify artemisinin and structurally-diverse natural products in plants extracts by NMR
por: García-García, Ana L., et al.
Publicado: (2023)

1-Benzyl-6-phenylimino-5-(pyrrol-2-ylidene)hexahydropyrimidine-2,4-dione
por: Tamazyan, Rafael, et al.
Publicado: (2008)

Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning
por: Tian, Yuan, et al.
Publicado: (2017)

Peptide bond planarity constrains hydrogen bond geometry and influences secondary structure conformations
por: Tan, Kuan Pern, et al.
Publicado: (2020)

Conformally invariant constrained fermion models
por: Cabra, D C, et al.
Publicado: (1990)

Constraining ribosomal RNA conformational space
por: Favaretto, Paola, et al.
Publicado: (2005)

Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection
por: Jang, In Seung, et al.
Publicado: (2016)

Relevance of hydroxyproline excretion to bone metastasis in breast cancer.
por: Gielen, F., et al.
Publicado: (1976)

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
por: Soares, Pedro, et al.
Publicado: (2018)

STUDIES ON THE BIOSYNTHESIS OF COLLAGEN : II. THE CONVERSION OF(14)C-L-PROLINE TO(14)C-HYDROXYPROLINE BY FOWL OSTEOBLASTS IN TISSUE CULTURE
por: Smith, R. H., et al.
Publicado: (1957)

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
por: Suparpprom, Chaturong, et al.
Publicado: (2022)

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
por: Testa, Andrea, et al.
Publicado: (2018)

Hollow Silica Cubes with Customizable Porosity
por: Gallagher, Samuel Hugh, et al.
Publicado: (2020)

Optically activated, customizable, excitable cells
por: Thomas, Merrilee, et al.
Publicado: (2020)

Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities
por: Xie, Linlin, et al.
Publicado: (2018)

Total urinary and free serum hydroxyproline in metastatic bone disease.
por: Gasser, A. B., et al.
Publicado: (1979)

Three-centre study on urinary hydroxyproline excretion in cancer of the breast.
por: Cuschieri, A., et al.
Publicado: (1978)

Bioinformatic Identification and Analysis of Hydroxyproline-Rich Glycoproteins in Populus trichocarpa
por: Showalter, Allan M., et al.
Publicado: (2016)

Using pentosidine and hydroxyproline to predict age and sex in an avian species
por: Dorr, Brian S., et al.
Publicado: (2017)

Identification of Hydroxyproline-Containing Proteins and Hydroxylation of Proline Residues in Rice
por: Liang, Ronghong, et al.
Publicado: (2020)

Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice
por: Young, Jonathan A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lli90rt60nrl3vas92q76qje55