Mechanistic and Structural Insights into a Divergent PLP-Dependent l-Enduracididine Cyclase from a Toxic Cyanobacterium

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[Image: see text] Cyclic arginine noncanonical amino acids (ncAAs) are found in several actinobacterial peptide natural products with therapeutically useful antibacterial properties. The preparation of ncAAs like enduracididine and capreomycidine currently takes multiple biosynthetic or chemosynthet...

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Autores principales: Cordoza, Jennifer L., Chen, Percival Yang-Ting, Blaustein, Linnea R., Lima, Stella T., Fiore, Marli F., Chekan, Jonathan R., Moore, Bradley S., McKinnie, Shaun M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367076/
https://www.ncbi.nlm.nih.gov/pubmed/37497377
http://dx.doi.org/10.1021/acscatal.3c01294
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