Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors

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[Image: see text] Protein-based switches that respond to different inputs to regulate cellular outputs, such as gene expression, are central to synthetic biology. For increased controllability, multi-input switches that integrate several cooperating and competing signals for the regulation of a shar...

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Detalles Bibliográficos
Autores principales: Kretschmer, Simon, Perry, Nicholas, Zhang, Yang, Kortemme, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367131/
https://www.ncbi.nlm.nih.gov/pubmed/37315218
http://dx.doi.org/10.1021/acssynbio.3c00080

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