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Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223
[Image: see text] A low-cost, protecting group-free route to 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane (1), the starting material for the in-development tuberculosis treatment TBI-223, is described. The key bond forming step in this route is the creation of the azetidine ring through a...
Autores principales: | Cardoso, Flavio S.P., Kadam, Appasaheb L., Nelson, Ryan C., Tomlin, John W., Dahal, Dipendra, Kuehner, Christopher S., Gudvangen, Gard, Arduengo, Anthony J., Burns, Justina M., Aleshire, Sarah L., Snead, David R., Qu, Fengrui, Belmore, Ken, Ahmad, Saeed, Agrawal, Toolika, Sieber, Joshua D., Donsbach, Kai Oliver |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367134/ https://www.ncbi.nlm.nih.gov/pubmed/37496954 http://dx.doi.org/10.1021/acs.oprd.3c00148 |
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