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Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

BACKGROUND: Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass. METHODS: This study was a cr...

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Autores principales: Shi, Lin, Zhang, Liang, Zhang, Dan, Chen, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367418/
https://www.ncbi.nlm.nih.gov/pubmed/37488531
http://dx.doi.org/10.1186/s12889-023-16338-8
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author Shi, Lin
Zhang, Liang
Zhang, Dan
Chen, Zhuo
author_facet Shi, Lin
Zhang, Liang
Zhang, Dan
Chen, Zhuo
author_sort Shi, Lin
collection PubMed
description BACKGROUND: Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass. METHODS: This study was a cross-sectional study based on National Health and Nutrition Examination Survey (2011–2018). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Appendicular skeletal muscle index was used to define low muscle mass. The individuals were divided into four groups by the quartile of SII (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting and subgroup analysis were used to investigate the relationship between SII and sarcopenia. Subgroup analysis were based on demographic and clinical variables. RESULTS: There were 10,367 individuals enrolled in our final analysis. The overall mean age was 39.39 years and 49.17% were males. The overall prevalence of low muscle mass in the study population was 8.77%. The smooth curve fitting analysis indicated a near-linear relationship between SII and low muscle mass. In multivariate weighted logistic regression analysis, the odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16–1.40) for low muscle mass when compared to lowest quartile of the SII. In subgroup analysis, SII still increased the risk of low muscle mass independently. CONCLUSION: The increased SII levels were associated with an increased risk of low muscle mass in a large population. Our study increased the understanding between inflammation and low muscle mass. Anti-inflammation therapy may be important for low muscle mass.
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spelling pubmed-103674182023-07-26 Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study Shi, Lin Zhang, Liang Zhang, Dan Chen, Zhuo BMC Public Health Research BACKGROUND: Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass. METHODS: This study was a cross-sectional study based on National Health and Nutrition Examination Survey (2011–2018). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Appendicular skeletal muscle index was used to define low muscle mass. The individuals were divided into four groups by the quartile of SII (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting and subgroup analysis were used to investigate the relationship between SII and sarcopenia. Subgroup analysis were based on demographic and clinical variables. RESULTS: There were 10,367 individuals enrolled in our final analysis. The overall mean age was 39.39 years and 49.17% were males. The overall prevalence of low muscle mass in the study population was 8.77%. The smooth curve fitting analysis indicated a near-linear relationship between SII and low muscle mass. In multivariate weighted logistic regression analysis, the odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16–1.40) for low muscle mass when compared to lowest quartile of the SII. In subgroup analysis, SII still increased the risk of low muscle mass independently. CONCLUSION: The increased SII levels were associated with an increased risk of low muscle mass in a large population. Our study increased the understanding between inflammation and low muscle mass. Anti-inflammation therapy may be important for low muscle mass. BioMed Central 2023-07-24 /pmc/articles/PMC10367418/ /pubmed/37488531 http://dx.doi.org/10.1186/s12889-023-16338-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shi, Lin
Zhang, Liang
Zhang, Dan
Chen, Zhuo
Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title_full Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title_fullStr Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title_full_unstemmed Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title_short Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
title_sort association between systemic immune-inflammation index and low muscle mass in us adults: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367418/
https://www.ncbi.nlm.nih.gov/pubmed/37488531
http://dx.doi.org/10.1186/s12889-023-16338-8
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