Construction of CD19 targeted dual- and enhanced dual-antibodies and their efficiency in the treatment of B cell malignancy

BACKGROUND: T cell-redirecting bispecific antibodies establish a connection between endogenous T cells and tumor cells, activating T cells function to eliminate tumor cells without ex vivo genetic alteration or manipulation. Here, we developed a novel dual-specific antibody (DuAb) and an enhanced Du...

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Detalles Bibliográficos
Autores principales: Chen, Manling, Liu, Xiaoyu, Peng, Nan, Zhang, Ting, Mou, Junli, He, Huizhen, Wang, Ying, Xu, Yingxi, Xing, Haiyan, Tang, Kejing, Tian, Zheng, Rao, Qing, Gu, Runxia, Qiu, Shaowei, Wang, Min, Wang, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367426/
https://www.ncbi.nlm.nih.gov/pubmed/37488603
http://dx.doi.org/10.1186/s40164-023-00423-0

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