HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex

The development of boron agents with integrated functionality, including biocompatibility, high boron content, and cancer cell targeting, is desired to exploit the therapeutic efficacy of boron neutron capture therapy (BNCT). Here, we report the therapeutic efficacy of BNCT using a HER-2-targeted an...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamana, Keita, Kawasaki, Riku, Kondo, Kousuke, Hirano, Hidetoshi, Kawamura, Shogo, Sanada, Yu, Bando, Kaori, Tabata, Anri, Azuma, Hideki, Takata, Takushi, Sakurai, Yoshinori, Tanaka, Hiroki, Kodama, Tomoki, Kawamoto, Seiji, Nagasaki, Takeshi, Ikeda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367957/
https://www.ncbi.nlm.nih.gov/pubmed/37496630
http://dx.doi.org/10.1039/d3na00028a
_version_ 1785077419688853504
author Yamana, Keita
Kawasaki, Riku
Kondo, Kousuke
Hirano, Hidetoshi
Kawamura, Shogo
Sanada, Yu
Bando, Kaori
Tabata, Anri
Azuma, Hideki
Takata, Takushi
Sakurai, Yoshinori
Tanaka, Hiroki
Kodama, Tomoki
Kawamoto, Seiji
Nagasaki, Takeshi
Ikeda, Atsushi
author_facet Yamana, Keita
Kawasaki, Riku
Kondo, Kousuke
Hirano, Hidetoshi
Kawamura, Shogo
Sanada, Yu
Bando, Kaori
Tabata, Anri
Azuma, Hideki
Takata, Takushi
Sakurai, Yoshinori
Tanaka, Hiroki
Kodama, Tomoki
Kawamoto, Seiji
Nagasaki, Takeshi
Ikeda, Atsushi
author_sort Yamana, Keita
collection PubMed
description The development of boron agents with integrated functionality, including biocompatibility, high boron content, and cancer cell targeting, is desired to exploit the therapeutic efficacy of boron neutron capture therapy (BNCT). Here, we report the therapeutic efficacy of BNCT using a HER-2-targeted antibody-conjugated boron nitride nanotube/β-1,3-glucan complex. The anticancer effect of BNCT using our system was 30-fold that of the clinically available boron agent l-BPA/fructose complex.
format Online
Article
Text
id pubmed-10367957
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher RSC
record_format MEDLINE/PubMed
spelling pubmed-103679572023-07-26 HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex Yamana, Keita Kawasaki, Riku Kondo, Kousuke Hirano, Hidetoshi Kawamura, Shogo Sanada, Yu Bando, Kaori Tabata, Anri Azuma, Hideki Takata, Takushi Sakurai, Yoshinori Tanaka, Hiroki Kodama, Tomoki Kawamoto, Seiji Nagasaki, Takeshi Ikeda, Atsushi Nanoscale Adv Chemistry The development of boron agents with integrated functionality, including biocompatibility, high boron content, and cancer cell targeting, is desired to exploit the therapeutic efficacy of boron neutron capture therapy (BNCT). Here, we report the therapeutic efficacy of BNCT using a HER-2-targeted antibody-conjugated boron nitride nanotube/β-1,3-glucan complex. The anticancer effect of BNCT using our system was 30-fold that of the clinically available boron agent l-BPA/fructose complex. RSC 2023-06-01 /pmc/articles/PMC10367957/ /pubmed/37496630 http://dx.doi.org/10.1039/d3na00028a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yamana, Keita
Kawasaki, Riku
Kondo, Kousuke
Hirano, Hidetoshi
Kawamura, Shogo
Sanada, Yu
Bando, Kaori
Tabata, Anri
Azuma, Hideki
Takata, Takushi
Sakurai, Yoshinori
Tanaka, Hiroki
Kodama, Tomoki
Kawamoto, Seiji
Nagasaki, Takeshi
Ikeda, Atsushi
HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title_full HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title_fullStr HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title_full_unstemmed HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title_short HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
title_sort her-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367957/
https://www.ncbi.nlm.nih.gov/pubmed/37496630
http://dx.doi.org/10.1039/d3na00028a
work_keys_str_mv AT yamanakeita her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT kawasakiriku her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT kondokousuke her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT hiranohidetoshi her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT kawamurashogo her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT sanadayu her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT bandokaori her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT tabataanri her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT azumahideki her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT takatatakushi her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT sakuraiyoshinori her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT tanakahiroki her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT kodamatomoki her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT kawamotoseiji her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT nagasakitakeshi her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex
AT ikedaatsushi her2targetedboronneutroncapturetherapyusinganantibodyconjugatedboronnitridenanotubeb13glucancomplex

Ejemplares similares