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Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging

A new formulation of the lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample model called the dispersed scatterer model (DSM), in which...

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Autores principales: Tomita, Kiriko, Makita, Shuichi, Fukutake, Naoki, Morishita, Rion, Abd El-Sadek, Ibrahim, Mukherjee, Pradipta, Lichtenegger, Antonia, Tamaoki, Junya, Bian, Lixuan, Kobayashi, Makoto, Mori, Tomoko, Matsusaka, Satoshi, Yasuno, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optica Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368023/
https://www.ncbi.nlm.nih.gov/pubmed/37497522
http://dx.doi.org/10.1364/BOE.491510
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author Tomita, Kiriko
Makita, Shuichi
Fukutake, Naoki
Morishita, Rion
Abd El-Sadek, Ibrahim
Mukherjee, Pradipta
Lichtenegger, Antonia
Tamaoki, Junya
Bian, Lixuan
Kobayashi, Makoto
Mori, Tomoko
Matsusaka, Satoshi
Yasuno, Yoshiaki
author_facet Tomita, Kiriko
Makita, Shuichi
Fukutake, Naoki
Morishita, Rion
Abd El-Sadek, Ibrahim
Mukherjee, Pradipta
Lichtenegger, Antonia
Tamaoki, Junya
Bian, Lixuan
Kobayashi, Makoto
Mori, Tomoko
Matsusaka, Satoshi
Yasuno, Yoshiaki
author_sort Tomita, Kiriko
collection PubMed
description A new formulation of the lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample model called the dispersed scatterer model (DSM), in which the sample is represented as a material with a spatially slowly varying refractive index and randomly distributed scatterers embedded in the material. It is shown that the formulation represents a meaningful OCT image and speckle as two independent mathematical quantities. The new differential contrast method is based on complex signal processing of OCT images, and the physical and numerical imaging processes of this method are jointly formulated using the same theoretical strategy as in the case of OCT. The formula shows that the method provides a spatially differential image of the sample structure. This differential imaging method is validated by measuring in vivo and in vitro samples.
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spelling pubmed-103680232023-07-26 Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging Tomita, Kiriko Makita, Shuichi Fukutake, Naoki Morishita, Rion Abd El-Sadek, Ibrahim Mukherjee, Pradipta Lichtenegger, Antonia Tamaoki, Junya Bian, Lixuan Kobayashi, Makoto Mori, Tomoko Matsusaka, Satoshi Yasuno, Yoshiaki Biomed Opt Express Article A new formulation of the lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample model called the dispersed scatterer model (DSM), in which the sample is represented as a material with a spatially slowly varying refractive index and randomly distributed scatterers embedded in the material. It is shown that the formulation represents a meaningful OCT image and speckle as two independent mathematical quantities. The new differential contrast method is based on complex signal processing of OCT images, and the physical and numerical imaging processes of this method are jointly formulated using the same theoretical strategy as in the case of OCT. The formula shows that the method provides a spatially differential image of the sample structure. This differential imaging method is validated by measuring in vivo and in vitro samples. Optica Publishing Group 2023-06-06 /pmc/articles/PMC10368023/ /pubmed/37497522 http://dx.doi.org/10.1364/BOE.491510 Text en Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tomita, Kiriko
Makita, Shuichi
Fukutake, Naoki
Morishita, Rion
Abd El-Sadek, Ibrahim
Mukherjee, Pradipta
Lichtenegger, Antonia
Tamaoki, Junya
Bian, Lixuan
Kobayashi, Makoto
Mori, Tomoko
Matsusaka, Satoshi
Yasuno, Yoshiaki
Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title_full Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title_fullStr Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title_full_unstemmed Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title_short Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
title_sort theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368023/
https://www.ncbi.nlm.nih.gov/pubmed/37497522
http://dx.doi.org/10.1364/BOE.491510
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