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Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]

Over the past several decades, near-infrared spectroscopy (NIRS) has become a popular research and clinical tool for non-invasively measuring the oxygenation of biological tissues, with particular emphasis on applications to the human brain. In most cases, NIRS studies are performed using continuous...

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Autores principales: Zhou, Xinkai, Xia, Yunjia, Uchitel, Julie, Collins-Jones, Liam, Yang, Shufan, Loureiro, Rui, Cooper, Robert J., Zhao, Hubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optica Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368025/
https://www.ncbi.nlm.nih.gov/pubmed/37497520
http://dx.doi.org/10.1364/BOE.484044
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author Zhou, Xinkai
Xia, Yunjia
Uchitel, Julie
Collins-Jones, Liam
Yang, Shufan
Loureiro, Rui
Cooper, Robert J.
Zhao, Hubin
author_facet Zhou, Xinkai
Xia, Yunjia
Uchitel, Julie
Collins-Jones, Liam
Yang, Shufan
Loureiro, Rui
Cooper, Robert J.
Zhao, Hubin
author_sort Zhou, Xinkai
collection PubMed
description Over the past several decades, near-infrared spectroscopy (NIRS) has become a popular research and clinical tool for non-invasively measuring the oxygenation of biological tissues, with particular emphasis on applications to the human brain. In most cases, NIRS studies are performed using continuous-wave NIRS (CW-NIRS), which can only provide information on relative changes in chromophore concentrations, such as oxygenated and deoxygenated hemoglobin, as well as estimates of tissue oxygen saturation. Another type of NIRS known as frequency-domain NIRS (FD-NIRS) has significant advantages: it can directly measure optical pathlength and thus quantify the scattering and absorption coefficients of sampled tissues and provide direct measurements of absolute chromophore concentrations. This review describes the current status of FD-NIRS technologies, their performance, their advantages, and their limitations as compared to other NIRS methods. Significant landmarks of technological progress include the development of both benchtop and portable/wearable FD-NIRS technologies, sensitive front-end photonic components, and high-frequency phase measurements. Clinical applications of FD-NIRS technologies are discussed to provide context on current applications and needed areas of improvement. The review concludes by providing a roadmap toward the next generation of fully wearable, low-cost FD-NIRS systems.
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spelling pubmed-103680252023-07-26 Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited] Zhou, Xinkai Xia, Yunjia Uchitel, Julie Collins-Jones, Liam Yang, Shufan Loureiro, Rui Cooper, Robert J. Zhao, Hubin Biomed Opt Express Article Over the past several decades, near-infrared spectroscopy (NIRS) has become a popular research and clinical tool for non-invasively measuring the oxygenation of biological tissues, with particular emphasis on applications to the human brain. In most cases, NIRS studies are performed using continuous-wave NIRS (CW-NIRS), which can only provide information on relative changes in chromophore concentrations, such as oxygenated and deoxygenated hemoglobin, as well as estimates of tissue oxygen saturation. Another type of NIRS known as frequency-domain NIRS (FD-NIRS) has significant advantages: it can directly measure optical pathlength and thus quantify the scattering and absorption coefficients of sampled tissues and provide direct measurements of absolute chromophore concentrations. This review describes the current status of FD-NIRS technologies, their performance, their advantages, and their limitations as compared to other NIRS methods. Significant landmarks of technological progress include the development of both benchtop and portable/wearable FD-NIRS technologies, sensitive front-end photonic components, and high-frequency phase measurements. Clinical applications of FD-NIRS technologies are discussed to provide context on current applications and needed areas of improvement. The review concludes by providing a roadmap toward the next generation of fully wearable, low-cost FD-NIRS systems. Optica Publishing Group 2023-06-12 /pmc/articles/PMC10368025/ /pubmed/37497520 http://dx.doi.org/10.1364/BOE.484044 Text en Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhou, Xinkai
Xia, Yunjia
Uchitel, Julie
Collins-Jones, Liam
Yang, Shufan
Loureiro, Rui
Cooper, Robert J.
Zhao, Hubin
Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title_full Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title_fullStr Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title_full_unstemmed Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title_short Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited]
title_sort review of recent advances in frequency-domain near-infrared spectroscopy technologies [invited]
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368025/
https://www.ncbi.nlm.nih.gov/pubmed/37497520
http://dx.doi.org/10.1364/BOE.484044
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