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Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report
Here, we present a 69-year-old female with advanced neuroendocrine carcinoma (NEC) of colon with multiple liver, bone, and kidney metastases who developed Trousseau’s syndrome. The patient received etoposide plus cisplatin (EP) as the first-line therapy; however, after single administration of EP, s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368095/ https://www.ncbi.nlm.nih.gov/pubmed/37497422 http://dx.doi.org/10.1159/000530927 |
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author | Ohmura, Hirofumi Tobo, Taro Mimori, Koshi Baba, Eishi Horiuchi, Takahiko |
author_facet | Ohmura, Hirofumi Tobo, Taro Mimori, Koshi Baba, Eishi Horiuchi, Takahiko |
author_sort | Ohmura, Hirofumi |
collection | PubMed |
description | Here, we present a 69-year-old female with advanced neuroendocrine carcinoma (NEC) of colon with multiple liver, bone, and kidney metastases who developed Trousseau’s syndrome. The patient received etoposide plus cisplatin (EP) as the first-line therapy; however, after single administration of EP, she developed the severe lower-limb edema and EP was considered to be intolerable. Etoposide plus carboplatin was administered as the second-line therapy and after 3 cycles of administration, the progressive disease (PD) was confirmed and 5-fluorouracil + leucovorin + irinotecan (FOLFIRI) plus ramucirumab was administered as the third-line therapy. However, PD was confirmed after 3 cycles of the therapy, and she was to receive the best supportive care and was hospitalized in our hospital. Four weeks after hospitalization, mild impaired consciousness and dysarthria were observed. Blood tests showed coagulation abnormalities including elevation of plasma fibrin/fibrinogen degradation products (FDPs) and D-dimer levels, and the diffusion-weighted image of magnetic resonance imaging (MRI) of the head showed multiple cerebral infarcts. She was diagnosed with Trousseau’s syndrome due to the progression of NEC and intravenous unfractionated heparin was administered as anticoagulant therapy. After the administration of heparin, plasma FDP and D-dimer levels decreased; however, due to the progression of NEC, the patient died 6 weeks after hospitalization. This is the first report of NEC of the colon that developed Trousseau’s syndrome. |
format | Online Article Text |
id | pubmed-10368095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-103680952023-07-26 Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report Ohmura, Hirofumi Tobo, Taro Mimori, Koshi Baba, Eishi Horiuchi, Takahiko Case Rep Oncol Case Report Here, we present a 69-year-old female with advanced neuroendocrine carcinoma (NEC) of colon with multiple liver, bone, and kidney metastases who developed Trousseau’s syndrome. The patient received etoposide plus cisplatin (EP) as the first-line therapy; however, after single administration of EP, she developed the severe lower-limb edema and EP was considered to be intolerable. Etoposide plus carboplatin was administered as the second-line therapy and after 3 cycles of administration, the progressive disease (PD) was confirmed and 5-fluorouracil + leucovorin + irinotecan (FOLFIRI) plus ramucirumab was administered as the third-line therapy. However, PD was confirmed after 3 cycles of the therapy, and she was to receive the best supportive care and was hospitalized in our hospital. Four weeks after hospitalization, mild impaired consciousness and dysarthria were observed. Blood tests showed coagulation abnormalities including elevation of plasma fibrin/fibrinogen degradation products (FDPs) and D-dimer levels, and the diffusion-weighted image of magnetic resonance imaging (MRI) of the head showed multiple cerebral infarcts. She was diagnosed with Trousseau’s syndrome due to the progression of NEC and intravenous unfractionated heparin was administered as anticoagulant therapy. After the administration of heparin, plasma FDP and D-dimer levels decreased; however, due to the progression of NEC, the patient died 6 weeks after hospitalization. This is the first report of NEC of the colon that developed Trousseau’s syndrome. S. Karger AG 2023-07-03 /pmc/articles/PMC10368095/ /pubmed/37497422 http://dx.doi.org/10.1159/000530927 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Ohmura, Hirofumi Tobo, Taro Mimori, Koshi Baba, Eishi Horiuchi, Takahiko Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title | Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title_full | Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title_fullStr | Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title_full_unstemmed | Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title_short | Trousseau’s Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report |
title_sort | trousseau’s syndrome with advanced neuroendocrine carcinoma of colon: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368095/ https://www.ncbi.nlm.nih.gov/pubmed/37497422 http://dx.doi.org/10.1159/000530927 |
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