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Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report

A rare case of occult cytomegalovirus (CMV) cholangitis along with an updated literature review is presented. The patient had not undergone solid organ–bone marrow transplantation and had no chronic autoimmune biliary tract disorder or obvious immunodeficiency. The patient had underwent a pyloric-sp...

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Autores principales: Mastroianni, Antonio, Greco, Sonia, Vangeli, Valeria, Mauro, Maria Vittoria, Greco, Francesca, Manfredi, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368214/
http://dx.doi.org/10.1097/ID9.0000000000000093
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author Mastroianni, Antonio
Greco, Sonia
Vangeli, Valeria
Mauro, Maria Vittoria
Greco, Francesca
Manfredi, Roberto
author_facet Mastroianni, Antonio
Greco, Sonia
Vangeli, Valeria
Mauro, Maria Vittoria
Greco, Francesca
Manfredi, Roberto
author_sort Mastroianni, Antonio
collection PubMed
description A rare case of occult cytomegalovirus (CMV) cholangitis along with an updated literature review is presented. The patient had not undergone solid organ–bone marrow transplantation and had no chronic autoimmune biliary tract disorder or obvious immunodeficiency. The patient had underwent a pyloric-sparing duodenocephalopancreasectomy, and the postoperative histopathologic examination revealed multiple ulcerative lesions and an occult CMV infection. The copy number of CMV DNA was high (38,000 copies/μg DNA) in common bile duct surgical specimens measured by real-time quantitative polymerase chain reaction. CMV was not detected in blood and urine samples from the patient after full doses of intravenous ganciclovir and full doses of oral valganciclovir antiviral therapy. This report recapitulates the role of CMV in causing severe cholangiopathy in the absence of obvious immunosuppression or autoimmune disorder of the biliary tract.
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spelling pubmed-103682142023-07-26 Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report Mastroianni, Antonio Greco, Sonia Vangeli, Valeria Mauro, Maria Vittoria Greco, Francesca Manfredi, Roberto Medicine (Baltimore) Case Report A rare case of occult cytomegalovirus (CMV) cholangitis along with an updated literature review is presented. The patient had not undergone solid organ–bone marrow transplantation and had no chronic autoimmune biliary tract disorder or obvious immunodeficiency. The patient had underwent a pyloric-sparing duodenocephalopancreasectomy, and the postoperative histopathologic examination revealed multiple ulcerative lesions and an occult CMV infection. The copy number of CMV DNA was high (38,000 copies/μg DNA) in common bile duct surgical specimens measured by real-time quantitative polymerase chain reaction. CMV was not detected in blood and urine samples from the patient after full doses of intravenous ganciclovir and full doses of oral valganciclovir antiviral therapy. This report recapitulates the role of CMV in causing severe cholangiopathy in the absence of obvious immunosuppression or autoimmune disorder of the biliary tract. Lippincott Williams & Wilkins 2023-07 2023-07-20 /pmc/articles/PMC10368214/ http://dx.doi.org/10.1097/ID9.0000000000000093 Text en Copyright © 2023 The Chinese Medical Association, published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Mastroianni, Antonio
Greco, Sonia
Vangeli, Valeria
Mauro, Maria Vittoria
Greco, Francesca
Manfredi, Roberto
Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title_full Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title_fullStr Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title_full_unstemmed Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title_short Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report
title_sort occult cytomegalovirus cholangitis and pancreatic adenocarcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368214/
http://dx.doi.org/10.1097/ID9.0000000000000093
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