A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity

BACKGROUND: The parasitic filariae responsible for onchocerciasis and lymphatic filariasis are host to an endosymbiotic bacterium, Wolbachia, which is essential to the fertility and development of the parasites. We performed a Phase-I pharmacokinetic, safety and food-effect study on single and multi...

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Detalles Bibliográficos
Autores principales: Alami, Negar, Carter, David C., Kwatra, Nisha V., Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R., Klein, Cheri E., Cohen, Daniel E., Gallenberg, Loretta, Neenan, Melina, Carr, Robert A., Marsh, Kennan C., Kempf, Dale J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368248/
https://www.ncbi.nlm.nih.gov/pubmed/37428804
http://dx.doi.org/10.1371/journal.pntd.0011392

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