Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)—An open-label, single-arm Simon’s two stage phase 1 study protocol

BACKGROUND: Pediatric acute liver failure (PALF) carries a high mortality without liver transplantation (LT) in children. Liver transplantation, though lifesaving, is limited by timely donor organ availability, the risks of major surgery and complications of life-long immunosuppression. Hepatocyte t...

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Detalles Bibliográficos
Autores principales: Fitzpatrick, Emer, Filippi, Celine, Jagadisan, Barath, Shivapatham, Dharshene, Anand, Hanish, Lyne, Mike, Stroud, Katherine-Daisy, Newton, Rebecca, DeLord, Marc, Douiri, Abdel, Dhawan, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368261/
https://www.ncbi.nlm.nih.gov/pubmed/37490429
http://dx.doi.org/10.1371/journal.pone.0288185

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