Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Molecular routes to metastatic dissemination are critical determinants of aggressive cancers. Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically engineered models that faithfully recapitulate metastatic renal tumors. Disruption of 9p21 locus is an evolutionary driver...

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Detalles Bibliográficos
Autores principales: Perelli, Luigi, Carbone, Federica, Zhang, Li, Huang, Justin K., Le, Courtney, Khan, Hania, Citron, Francesca, Del Poggetto, Edoardo, Gutschner, Tony, Tomihara, Hideo, Soeung, Melinda, Minelli, Rosalba, Srinivasan, Sanjana, Peoples, Michael, Lam, Truong Nguyen Anh, Lundgren, Sebastian, Xia, Ruohan, Zhu, Cihui, Mohamed, Alaa M. T., Zhang, Jianhua, Sircar, Kanishka, Sgambato, Alessandro, Gao, JianJun, Jonasch, Eric, Draetta, Giulio F., Futreal, Andrew, Bakouny, Ziad, Van Allen, Eliezer M., Choueiri, Toni, Signoretti, Sabina, Msaouel, Pavlos, Litchfield, Kevin, Turajlic, Samra, Wang, Linghua, Chen, Ying Bei, Di Natale, Renzo G., Hakimi, A. Ari, Giuliani, Virginia, Heffernan, Timothy P., Viale, Andrea, Bristow, Christopher A., Tannir, Nizar M., Carugo, Alessandro, Genovese, Giannicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368532/
https://www.ncbi.nlm.nih.gov/pubmed/37365326
http://dx.doi.org/10.1038/s43018-023-00584-1

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