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A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP)
Patients with cancer are at increased risk of hospitalisation and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV-2 phenotype evolution in patients with cancer since 2020 has not previously been described. We therefore evaluated SARS-...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368624/ https://www.ncbi.nlm.nih.gov/pubmed/37491478 http://dx.doi.org/10.1038/s41598-023-36990-9 |
| _version_ | 1785077542306185216 |
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| author | Starkey, Thomas Ionescu, Maria C. Tilby, Michael Little, Martin Burke, Emma Fittall, Matthew W. Khan, Sam Liu, Justin K. H. Platt, James R. Mew, Rosie Tripathy, Arvind R. Watts, Isabella Williams, Sophie Therese Appanna, Nathan Al-Hajji, Youssra Barnard, Matthew Benny, Liza Burnett, Alexander Bytyci, Jola Cattell, Emma L. Cheng, Vinton Clark, James J. Eastlake, Leonie Gerrand, Kate Ghafoor, Qamar Grumett, Simon Harper-Wynne, Catherine Kahn, Rachel Lee, Alvin J. X. Lomas, Oliver Lydon, Anna Mckenzie, Hayley Panneerselvam, Hari Pascoe, Jennifer S. Patel, Grisma Patel, Vijay Potter, Vanessa A. Randle, Amelia Rigg, Anne S. Robinson, Tim M. Roylance, Rebecca Roques, Tom W. Rozmanowski, Stefan Roux, René L. Shah, Ketan Sheehan, Remarez Sintler, Martin Swarup, Sanskriti Taylor, Harriet Tillett, Tania Tuthill, Mark Williams, Sarah Ying, Yuxin Beggs, Andrew Iveson, Tim Lee, Siow Ming Middleton, Gary Middleton, Mark Protheroe, Andrew Fowler, Tom Johnson, Peter Lee, Lennard Y. W. |
| author_facet | Starkey, Thomas Ionescu, Maria C. Tilby, Michael Little, Martin Burke, Emma Fittall, Matthew W. Khan, Sam Liu, Justin K. H. Platt, James R. Mew, Rosie Tripathy, Arvind R. Watts, Isabella Williams, Sophie Therese Appanna, Nathan Al-Hajji, Youssra Barnard, Matthew Benny, Liza Burnett, Alexander Bytyci, Jola Cattell, Emma L. Cheng, Vinton Clark, James J. Eastlake, Leonie Gerrand, Kate Ghafoor, Qamar Grumett, Simon Harper-Wynne, Catherine Kahn, Rachel Lee, Alvin J. X. Lomas, Oliver Lydon, Anna Mckenzie, Hayley Panneerselvam, Hari Pascoe, Jennifer S. Patel, Grisma Patel, Vijay Potter, Vanessa A. Randle, Amelia Rigg, Anne S. Robinson, Tim M. Roylance, Rebecca Roques, Tom W. Rozmanowski, Stefan Roux, René L. Shah, Ketan Sheehan, Remarez Sintler, Martin Swarup, Sanskriti Taylor, Harriet Tillett, Tania Tuthill, Mark Williams, Sarah Ying, Yuxin Beggs, Andrew Iveson, Tim Lee, Siow Ming Middleton, Gary Middleton, Mark Protheroe, Andrew Fowler, Tom Johnson, Peter Lee, Lennard Y. W. |
| author_sort | Starkey, Thomas |
| collection | PubMed |
| description | Patients with cancer are at increased risk of hospitalisation and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV-2 phenotype evolution in patients with cancer since 2020 has not previously been described. We therefore evaluated SARS-CoV-2 on a UK populationscale from 01/11/2020-31/08/2022, assessing case-outcome rates of hospital assessment(s), intensive care admission and mortality. We observed that the SARS-CoV-2 disease phenotype has become less severe in patients with cancer and the non-cancer population. Case-hospitalisation rates for patients with cancer dropped from 30.58% in early 2021 to 7.45% in 2022 while case-mortality rates decreased from 20.53% to 3.25%. However, the risk of hospitalisation and mortality remains 2.10x and 2.54x higher in patients with cancer, respectively. Overall, the SARS-CoV-2 disease phenotype is less severe in 2022 compared to 2020 but patients with cancer remain at higher risk than the non-cancer population. Patients with cancer must therefore be empowered to live more normal lives, to see loved ones and families, while also being safeguarded with expanded measures to reduce the risk of transmission. |
| format | Online Article Text |
| id | pubmed-10368624 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103686242023-07-27 A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) Starkey, Thomas Ionescu, Maria C. Tilby, Michael Little, Martin Burke, Emma Fittall, Matthew W. Khan, Sam Liu, Justin K. H. Platt, James R. Mew, Rosie Tripathy, Arvind R. Watts, Isabella Williams, Sophie Therese Appanna, Nathan Al-Hajji, Youssra Barnard, Matthew Benny, Liza Burnett, Alexander Bytyci, Jola Cattell, Emma L. Cheng, Vinton Clark, James J. Eastlake, Leonie Gerrand, Kate Ghafoor, Qamar Grumett, Simon Harper-Wynne, Catherine Kahn, Rachel Lee, Alvin J. X. Lomas, Oliver Lydon, Anna Mckenzie, Hayley Panneerselvam, Hari Pascoe, Jennifer S. Patel, Grisma Patel, Vijay Potter, Vanessa A. Randle, Amelia Rigg, Anne S. Robinson, Tim M. Roylance, Rebecca Roques, Tom W. Rozmanowski, Stefan Roux, René L. Shah, Ketan Sheehan, Remarez Sintler, Martin Swarup, Sanskriti Taylor, Harriet Tillett, Tania Tuthill, Mark Williams, Sarah Ying, Yuxin Beggs, Andrew Iveson, Tim Lee, Siow Ming Middleton, Gary Middleton, Mark Protheroe, Andrew Fowler, Tom Johnson, Peter Lee, Lennard Y. W. Sci Rep Article Patients with cancer are at increased risk of hospitalisation and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV-2 phenotype evolution in patients with cancer since 2020 has not previously been described. We therefore evaluated SARS-CoV-2 on a UK populationscale from 01/11/2020-31/08/2022, assessing case-outcome rates of hospital assessment(s), intensive care admission and mortality. We observed that the SARS-CoV-2 disease phenotype has become less severe in patients with cancer and the non-cancer population. Case-hospitalisation rates for patients with cancer dropped from 30.58% in early 2021 to 7.45% in 2022 while case-mortality rates decreased from 20.53% to 3.25%. However, the risk of hospitalisation and mortality remains 2.10x and 2.54x higher in patients with cancer, respectively. Overall, the SARS-CoV-2 disease phenotype is less severe in 2022 compared to 2020 but patients with cancer remain at higher risk than the non-cancer population. Patients with cancer must therefore be empowered to live more normal lives, to see loved ones and families, while also being safeguarded with expanded measures to reduce the risk of transmission. Nature Publishing Group UK 2023-07-25 /pmc/articles/PMC10368624/ /pubmed/37491478 http://dx.doi.org/10.1038/s41598-023-36990-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Starkey, Thomas Ionescu, Maria C. Tilby, Michael Little, Martin Burke, Emma Fittall, Matthew W. Khan, Sam Liu, Justin K. H. Platt, James R. Mew, Rosie Tripathy, Arvind R. Watts, Isabella Williams, Sophie Therese Appanna, Nathan Al-Hajji, Youssra Barnard, Matthew Benny, Liza Burnett, Alexander Bytyci, Jola Cattell, Emma L. Cheng, Vinton Clark, James J. Eastlake, Leonie Gerrand, Kate Ghafoor, Qamar Grumett, Simon Harper-Wynne, Catherine Kahn, Rachel Lee, Alvin J. X. Lomas, Oliver Lydon, Anna Mckenzie, Hayley Panneerselvam, Hari Pascoe, Jennifer S. Patel, Grisma Patel, Vijay Potter, Vanessa A. Randle, Amelia Rigg, Anne S. Robinson, Tim M. Roylance, Rebecca Roques, Tom W. Rozmanowski, Stefan Roux, René L. Shah, Ketan Sheehan, Remarez Sintler, Martin Swarup, Sanskriti Taylor, Harriet Tillett, Tania Tuthill, Mark Williams, Sarah Ying, Yuxin Beggs, Andrew Iveson, Tim Lee, Siow Ming Middleton, Gary Middleton, Mark Protheroe, Andrew Fowler, Tom Johnson, Peter Lee, Lennard Y. W. A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title | A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title_full | A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title_fullStr | A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title_full_unstemmed | A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title_short | A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP) |
| title_sort | population-scale temporal case–control evaluation of covid-19 disease phenotype and related outcome rates in patients with cancer in england (ukccp) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368624/ https://www.ncbi.nlm.nih.gov/pubmed/37491478 http://dx.doi.org/10.1038/s41598-023-36990-9 |
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