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Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals
Short-wave infrared (SWIR) fluorescence could become the new gold standard in optical imaging for biomedical applications due to important advantages such as lack of autofluorescence, weak photon absorption by blood and tissues, and reduced photon scattering coefficient. Therefore, contrary to the v...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368714/ https://www.ncbi.nlm.nih.gov/pubmed/37491427 http://dx.doi.org/10.1038/s41467-023-40031-4 |
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author | Arteaga Cardona, Fernando Jain, Noopur Popescu, Radian Busko, Dmitry Madirov, Eduard Arús, Bernardo A. Gerthsen, Dagmar De Backer, Annick Bals, Sara Bruns, Oliver T. Chmyrov, Andriy Van Aert, Sandra Richards, Bryce S. Hudry, Damien |
author_facet | Arteaga Cardona, Fernando Jain, Noopur Popescu, Radian Busko, Dmitry Madirov, Eduard Arús, Bernardo A. Gerthsen, Dagmar De Backer, Annick Bals, Sara Bruns, Oliver T. Chmyrov, Andriy Van Aert, Sandra Richards, Bryce S. Hudry, Damien |
author_sort | Arteaga Cardona, Fernando |
collection | PubMed |
description | Short-wave infrared (SWIR) fluorescence could become the new gold standard in optical imaging for biomedical applications due to important advantages such as lack of autofluorescence, weak photon absorption by blood and tissues, and reduced photon scattering coefficient. Therefore, contrary to the visible and NIR regions, tissues become translucent in the SWIR region. Nevertheless, the lack of bright and biocompatible probes is a key challenge that must be overcome to unlock the full potential of SWIR fluorescence. Although rare-earth-based core-shell nanocrystals appeared as promising SWIR probes, they suffer from limited photoluminescence quantum yield (PLQY). The lack of control over the atomic scale organization of such complex materials is one of the main barriers limiting their optical performance. Here, the growth of either homogeneous (α-NaYF(4)) or heterogeneous (CaF(2)) shell domains on optically-active α-NaYF(4):Yb:Er (with and without Ce(3+) co-doping) core nanocrystals is reported. The atomic scale organization can be controlled by preventing cation intermixing only in heterogeneous core-shell nanocrystals with a dramatic impact on the PLQY. The latter reached 50% at 60 mW/cm(2); one of the highest reported PLQY values for sub-15 nm nanocrystals. The most efficient nanocrystals were utilized for in vivo imaging above 1450 nm. |
format | Online Article Text |
id | pubmed-10368714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103687142023-07-27 Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals Arteaga Cardona, Fernando Jain, Noopur Popescu, Radian Busko, Dmitry Madirov, Eduard Arús, Bernardo A. Gerthsen, Dagmar De Backer, Annick Bals, Sara Bruns, Oliver T. Chmyrov, Andriy Van Aert, Sandra Richards, Bryce S. Hudry, Damien Nat Commun Article Short-wave infrared (SWIR) fluorescence could become the new gold standard in optical imaging for biomedical applications due to important advantages such as lack of autofluorescence, weak photon absorption by blood and tissues, and reduced photon scattering coefficient. Therefore, contrary to the visible and NIR regions, tissues become translucent in the SWIR region. Nevertheless, the lack of bright and biocompatible probes is a key challenge that must be overcome to unlock the full potential of SWIR fluorescence. Although rare-earth-based core-shell nanocrystals appeared as promising SWIR probes, they suffer from limited photoluminescence quantum yield (PLQY). The lack of control over the atomic scale organization of such complex materials is one of the main barriers limiting their optical performance. Here, the growth of either homogeneous (α-NaYF(4)) or heterogeneous (CaF(2)) shell domains on optically-active α-NaYF(4):Yb:Er (with and without Ce(3+) co-doping) core nanocrystals is reported. The atomic scale organization can be controlled by preventing cation intermixing only in heterogeneous core-shell nanocrystals with a dramatic impact on the PLQY. The latter reached 50% at 60 mW/cm(2); one of the highest reported PLQY values for sub-15 nm nanocrystals. The most efficient nanocrystals were utilized for in vivo imaging above 1450 nm. Nature Publishing Group UK 2023-07-25 /pmc/articles/PMC10368714/ /pubmed/37491427 http://dx.doi.org/10.1038/s41467-023-40031-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Arteaga Cardona, Fernando Jain, Noopur Popescu, Radian Busko, Dmitry Madirov, Eduard Arús, Bernardo A. Gerthsen, Dagmar De Backer, Annick Bals, Sara Bruns, Oliver T. Chmyrov, Andriy Van Aert, Sandra Richards, Bryce S. Hudry, Damien Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title | Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title_full | Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title_fullStr | Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title_full_unstemmed | Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title_short | Preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
title_sort | preventing cation intermixing enables 50% quantum yield in sub-15 nm short-wave infrared-emitting rare-earth based core-shell nanocrystals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368714/ https://www.ncbi.nlm.nih.gov/pubmed/37491427 http://dx.doi.org/10.1038/s41467-023-40031-4 |
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